具有打印和抗菌导电水凝胶电极的柔性贴片，可加速伤口愈合。
Flexible patch with printable and antibacterial conductive hydrogel electrodes for accelerated wound healing.
机构信息
Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA; Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA; Department of Materials Science and Engineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA; Andrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, 91125, USA.
School of Nursing, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
出版信息
Biomaterials. 2022 Jun;285:121479. doi: 10.1016/j.biomaterials.2022.121479. Epub 2022 Apr 14.
Electrical stimulation can facilitate wound healing with high efficiency and limited side effects. However, current electrical stimulation devices have poor conformability with wounds due to their bulky nature and the rigidity of electrodes utilized. Here, a flexible electrical patch (ePatch) made with conductive hydrogel as electrodes to improve wound management was reported. The conductive hydrogel was synthesized using silver nanowire (AgNW) and methacrylated alginate (MAA), with the former chosen as the electrode material considering its antibacterial properties, and the latter used due to its clinical suitability in wound healing. The composition of the hydrogel was optimized to enable printing on medical-grade patches for personalized wound treatment. The ePatch was shown to promote re-epithelization, enhance angiogenesis, mediate immune response, and prevent infection development in the wound microenvironment. In vitro studies indicated an elevated secretion of growth factors with enhanced cell proliferation and migration ability in response to electrical stimulation. An in vivo study in the Sprague-Dawley rat model revealed a rapid wound closure within 7 days compared to 20 days of usual healing process in rodents.
电刺激可以高效、低副作用地促进伤口愈合。然而，由于现有电刺激设备体积庞大，电极僵硬，与伤口的贴合性较差。在这里，报道了一种使用导电水凝胶作为电极的柔性电贴片（ePatch），以改善伤口管理。导电水凝胶是使用银纳米线（AgNW）和甲基丙烯酰化藻酸盐（MAA）合成的，前者被选为电极材料，考虑到其抗菌性能，后者则因其在伤口愈合方面的临床适用性而被使用。水凝胶的组成经过优化，可在医用级贴片上打印，以实现个性化伤口治疗。ePatch 被证明可以促进再上皮化、增强血管生成、调节免疫反应，并防止伤口微环境中的感染发展。体外研究表明，在电刺激作用下，生长因子的分泌增加，细胞增殖和迁移能力增强。在 Sprague-Dawley 大鼠模型中的体内研究表明，与通常的啮齿动物 20 天愈合过程相比，7 天内伤口即可快速闭合。
Zotero 插件