Pharmcology Department, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan.
Department of Chemistry, Jinnah University for Women, Karachi, Pakistan.
Nat Prod Res. 2024 Jun;38(12):2019-2025. doi: 10.1080/14786419.2023.2233673. Epub 2023 Jul 17.
The work is aimed to evaluate the blood pressure reducing effect of constituents from methanol extract and associated constituents of flowers in normotensive and L-NAME induced hypertensive rats. The HPLC analysis of methanol extract of flowers (JFM) resulted in the quantitative identification and percent comparison of four phenolic constituents, protocatechuic acid (PA), methyl protocatechuate (MPA), patulitrin (TRIN) and patuletin (PAT). All the extracts, fractions and compounds examined showed significant blood pressure lowering activity. Patulitrin (TRIN) which has emerged as the major constituent (15.33%) of flowers showed significant 30% and 68% fall in blood pressure in normotensive and L-NAME induced hypertensive rats respectively. The patuletin (PAT), which is an aglycone of TRIN displayed high percentage (84%) of antihypertensive activity. Further, comprehensive and advanced studies on these constituents may result in preparation of an effective blood pressure lowering medicine with active precious rare flavonoids, patuletin and patulitrin.
本工作旨在评估甲醇提取物和花中相关成分在正常血压和 L-NAME 诱导的高血压大鼠中的降血压作用。花甲醇提取物（JFM）的 HPLC 分析导致了四种酚类成分的定量鉴定和百分比较，分别为原儿茶酸（PA）、甲基原儿茶酸（MPA）、芫花素（TRIN）和芫花素（PAT）。所有检查的提取物、馏分和化合物均显示出显著的降血压活性。芫花素（TRIN）作为花中的主要成分（15.33%），在正常血压和 L-NAME 诱导的高血压大鼠中分别显示出 30%和 68%的显著血压下降。TRIN 的苷元芫花素（PAT）表现出高百分比（84%）的降压活性。此外，对这些成分进行全面和先进的研究，可能会制备出一种有效的降压药物，其中含有活性珍贵的黄酮类化合物芫花素和芫花素。
