Shepherd H A, Barr G D, Jewell D P
J Clin Gastroenterol. 1986 Apr;8(2):154-9. doi: 10.1097/00004836-198604000-00010.
The efficacy of a 5-day intensive intravenous regimen (IVR), used as treatment for severely active Crohn's disease in 49 patients, has been evaluated retrospectively. The value of such systemic therapy has not been reported before. Immediate remission was achieved in 38 (76%) patients with no significant difference between those with established disease and those seen for the first time. Patients with ileocolonic disease had the poorest response. There was no apparent change in the natural history of the Crohn's disease after IVR therapy. Nevertheless, this is a safe and effective method of achieving remission in most sick patients with severely active Crohn's disease.
对49例重症活动性克罗恩病患者采用5天强化静脉治疗方案（IVR）进行治疗的疗效进行了回顾性评估。此前尚未报道过这种全身治疗方法的价值。38例（76%）患者实现了即刻缓解，疾病已确诊患者与初诊患者之间无显著差异。回结肠疾病患者的反应最差。IVR治疗后克罗恩病的自然病程无明显变化。然而，这是一种在大多数重症活动性克罗恩病患者中实现缓解的安全有效的方法。
