Sutherland L R
Division of Gastroenterology, University of Calgary, Alta.
CMAJ. 1987 Nov 1;137(9):799-802.
Ulcerative colitis, ulcerative proctitis and Crohn's disease are chronic inflammatory conditions that affect the gastrointestinal tract. Conventional treatment has stressed the role of anti-inflammatory agents to suppress the inflammatory response. New compounds that can deliver 5-aminosalicylic acid to the colon have recently been released in Canada. Metronidazole and azathioprine may also be of benefit in Crohn's disease. Therapy with cyclosporine and clonidine should be based on the results of further clinical trials. The use of nutritional support as primary therapy in Crohn's disease appears promising. At present, both pharmacologic and nutritional therapies should be considered in the treatment of inflammatory bowel disease.
溃疡性结肠炎、溃疡性直肠炎和克罗恩病是影响胃肠道的慢性炎症性疾病。传统治疗强调抗炎药在抑制炎症反应中的作用。最近，能将5-氨基水杨酸输送至结肠的新型化合物已在加拿大上市。甲硝唑和硫唑嘌呤对克罗恩病可能也有益处。环孢素和可乐定的治疗应基于进一步的临床试验结果。在克罗恩病中使用营养支持作为主要治疗方法似乎很有前景。目前，在炎症性肠病的治疗中应同时考虑药物治疗和营养治疗。
