Denham D A, Oxenham S L, Midwinter I, Friedheim E A
J Helminthol. 1986 Sep;60(3):169-72. doi: 10.1017/s0022149x00026043.
Mel W is a second generation anionic organic arsenical which is filaricidal but has sporadic and unacceptable lethal side effects. Eight new cationic derivatives have now been synthesized in an attempt to avoid the side effects and have been examined for their effects upon adult Brugia pahangi in Meriones unguiculatus. They were all shown to be potent filaricides and the two best compounds, Mel Ga and Mel Cy, were at least 95% effective in killing adult B. pahangi at 5 X 3.13 mg/kg when injected subcutaneously.
Mel W是第二代阴离子有机砷化合物，具有杀丝虫作用，但有偶发且不可接受的致命副作用。现已合成了八种新的阳离子衍生物，试图避免这些副作用，并对其对长爪沙鼠体内成年彭亨布鲁线虫的作用进行了研究。结果表明它们都是有效的杀丝虫剂，两种最佳化合物Mel Ga和Mel Cy，皮下注射时在5×3.13mg/kg剂量下对成年彭亨布鲁线虫的杀灭效果至少达95%。
