Surin J, Denham D A
London School of Hygiene and Tropical Medicine, England, UK.
J Helminthol. 1990 Sep;64(3):232-8. doi: 10.1017/s0022149x00012219.
It is possible to infect jirds with Brugia pahangi by three methods. Infective larvae (L3) can be injected either intraperitoneally (ip), when adults develop in the peritoneal cavity, or sub-cutaneously (sc), when they develop in the lymphatics or the heart and blood vessels associated with the lungs. Alternatively adult worms which have been grown in the peritoneal cavities of jirds can be implanted into the peritoneal cavities of other jirds. This latter system has been widely used for screening for new filaricides. We have compared the activity of 9 macrofilaricidal compounds against these 3 types of infection. Mebendazole and albendazole were more active against implanted adults than against L3 induced adults in the peritoneal cavity. Oxibendazole, flubendazole, CGP24588A and oxfendazole were equally active against both types of worm. CGP20376, Mel Ga and Mel Ni were more active against adult worms derived from inoculated L3 than implanted worms. When comparing intra-lymphatic and ip adults (both derived from L3 infections and in the same jirds) albendazole and CGP20376 were active at the same levels against both types of infection. Mebendazole, flubendazole, oxfendazole, CGP24588A, Mel Ga and Mel Ni were more active against ip adults than intra-lymphatic adults. No drug was more active against intra-lymphatic adults than against adults.
通过三种方法可以使沙鼠感染彭亨布鲁线虫。感染性幼虫（L3）可通过腹腔内注射（ip），成虫在腹腔内发育；或皮下注射（sc），成虫在淋巴管或与肺相关的心脏和血管中发育。另外，在沙鼠腹腔内生长的成虫可植入其他沙鼠的腹腔。后一种系统已被广泛用于筛选新的杀丝虫剂。我们比较了9种杀成虫化合物对这3种感染类型的活性。甲苯咪唑和阿苯达唑对植入的成虫比对腹腔内L3诱导产生的成虫更有效。奥苯达唑、氟苯达唑、CGP24588A和奥芬达唑对两种类型的虫体活性相同。CGP20376、Mel Ga和Mel Ni对接种L3产生的成虫比对植入的成虫更有效。比较淋巴管内成虫和腹腔内成虫（均源自L3感染且在同一只沙鼠体内）时，阿苯达唑和CGP20376对两种感染类型的活性水平相同。甲苯咪唑、氟苯达唑、奥芬达唑、CGP24588A、Mel Ga和Mel Ni对腹腔内成虫比对淋巴管内成虫更有效。没有一种药物对淋巴管内成虫比对成虫更有效。
