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Sleeping embryonic genomes are awoken by OBOX proteins.

作者信息

Wu Edlyn, Vastenhouw Nadine L

出版信息

Nature. 2023 Aug;620(7976):956-957. doi: 10.1038/d41586-023-01618-5.

DOI:10.1038/d41586-023-01618-5
PMID:37460688
Abstract
摘要

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Sleeping embryonic genomes are awoken by OBOX proteins.处于休眠状态的胚胎基因组会被OBOX蛋白唤醒。
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The sleep of co-sleeping infants when they are not co-sleeping: evidence that co-sleeping is stressful.同床共眠的婴儿在非同床共眠时的睡眠情况:证明同床共眠具有压力的证据。
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Sleep duration is affected by social relationships among sleeping partners in wild Japanese macaques.睡眠时长受野生日本猕猴睡眠伙伴间社会关系的影响。
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Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness.静息态功能磁共振成像在睡眠中的婴儿中更类似于成人睡眠而非成人清醒状态。
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The search for the molecular correlates of sleep and wakefulness.对睡眠与觉醒的分子关联的探索。
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[Electroencephalogram in children during wakefulness and during induced sleep].[儿童清醒和诱导睡眠期间的脑电图]
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Sleep/Wakefulness Detection Using Tracheal Sounds and Movements.利用气管声音和运动进行睡眠/觉醒检测。
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Sleep habits and sleep problems among a community sample of schoolchildren.社区学龄儿童样本中的睡眠习惯与睡眠问题
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引用本文的文献

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Maternal transcription factor OTX2 directly induces SETD1A and promotes embryonic genome activation in human pre-implantation embryos.母体转录因子OTX2直接诱导SETD1A并促进人类植入前胚胎中的胚胎基因组激活。
Sci China Life Sci. 2025 Apr 22. doi: 10.1007/s11427-024-2875-3.

本文引用的文献

1
Zygotic genome activation by the totipotency pioneer factor Nr5a2.全能性先驱因子Nr5a2介导的合子基因组激活
Science. 2022 Dec 23;378(6626):1305-1315. doi: 10.1126/science.abn7478. Epub 2022 Nov 24.
2
Metabolic and epigenetic dysfunctions underlie the arrest of in vitro fertilized human embryos in a senescent-like state.代谢和表观遗传功能障碍是体外受精的人类胚胎停滞在衰老样状态的基础。
PLoS Biol. 2022 Jun 30;20(6):e3001682. doi: 10.1371/journal.pbio.3001682. eCollection 2022 Jun.
3
CLAMP and Zelda function together to promote zygotic genome activation.
CLAMP 和 Zelda 共同作用促进合子基因组激活。
Elife. 2021 Aug 3;10:e69937. doi: 10.7554/eLife.69937.
4
GAF is essential for zygotic genome activation and chromatin accessibility in the early embryo.GAF 对于合子基因组激活和早期胚胎中的染色质可及性至关重要。
Elife. 2021 Mar 15;10:e66668. doi: 10.7554/eLife.66668.
5
The landscape of RNA Pol II binding reveals a stepwise transition during ZGA.RNA Pol II 结合景观揭示了合子基因组激活过程中的逐步转变。
Nature. 2020 Nov;587(7832):139-144. doi: 10.1038/s41586-020-2847-y. Epub 2020 Oct 28.
6
The maternal-to-zygotic transition revisited.重新审视母体到合子的过渡。
Development. 2019 Jun 12;146(11):dev161471. doi: 10.1242/dev.161471.
7
Loss of DUX causes minor defects in zygotic genome activation and is compatible with mouse development.DUX 的缺失导致合子基因组激活中的轻微缺陷,并且与小鼠的发育兼容。
Nat Genet. 2019 Jun;51(6):947-951. doi: 10.1038/s41588-019-0418-7. Epub 2019 May 27.
8
Minor zygotic gene activation is essential for mouse preimplantation development.少量的合子基因激活对于小鼠胚胎植入前发育是必需的。
Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6780-E6788. doi: 10.1073/pnas.1804309115. Epub 2018 Jul 2.
9
Mouse and modulate preimplantation transcriptional profiles revealing similarity between paralogous mouse and human homeobox genes.小鼠并调节植入前转录谱,揭示同源小鼠和人类同源框基因之间的相似性。
Evodevo. 2018 Jan 27;9:2. doi: 10.1186/s13227-018-0091-4. eCollection 2018.
10
Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons.小鼠DUX和人类DUX4在激活卵裂期基因和MERVL/HERVL逆转录转座子中的保守作用。
Nat Genet. 2017 Jun;49(6):925-934. doi: 10.1038/ng.3844. Epub 2017 May 1.