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A digital bridge to reverse paralysis.

作者信息

Hachem Laureen D, Balbinot Gustavo, Fehlings Michael G

机构信息

Division of Genetics and Development, Krembil Research Institute, University Health Network, Toronto, ON, Canada.

Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.

出版信息

Cell Res. 2023 Dec;33(12):892-893. doi: 10.1038/s41422-023-00845-9.

DOI:10.1038/s41422-023-00845-9
PMID:37460803
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10709562/
Abstract
摘要

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Neuromodulation to guide circuit reorganization with regenerative therapies in upper extremity rehabilitation following cervical spinal cord injury.在颈脊髓损伤后的上肢康复中,通过神经调节结合再生疗法来引导神经回路重组。
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本文引用的文献

1
Walking naturally after spinal cord injury using a brain-spine interface.使用脑-脊髓接口实现脊髓损伤后的自然行走。
Nature. 2023 Jun;618(7963):126-133. doi: 10.1038/s41586-023-06094-5. Epub 2023 May 24.
2
Epidural stimulation of the cervical spinal cord for post-stroke upper-limb paresis.脊髓硬膜外刺激治疗脑卒中后上肢瘫痪。
Nat Med. 2023 Mar;29(3):689-699. doi: 10.1038/s41591-022-02202-6. Epub 2023 Feb 20.
3
The neurons that restore walking after paralysis.瘫痪后恢复行走的神经元。
Nature. 2022 Nov;611(7936):540-547. doi: 10.1038/s41586-022-05385-7. Epub 2022 Nov 9.
4
Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys.颈背根硬膜外电刺激可恢复瘫痪猴子的上肢自主控制能力。
Nat Neurosci. 2022 Jul;25(7):924-934. doi: 10.1038/s41593-022-01106-5. Epub 2022 Jun 30.
5
Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis.活动依赖性脊髓神经调节可在完全瘫痪后迅速恢复躯干和腿部运动功能。
Nat Med. 2022 Feb;28(2):260-271. doi: 10.1038/s41591-021-01663-5. Epub 2022 Feb 7.
6
Targeted neurotechnology restores walking in humans with spinal cord injury.靶向神经技术恢复脊髓损伤患者的行走能力。
Nature. 2018 Nov;563(7729):65-71. doi: 10.1038/s41586-018-0649-2. Epub 2018 Oct 31.
7
A brain-spine interface alleviating gait deficits after spinal cord injury in primates.一种减轻灵长类动物脊髓损伤后步态缺陷的脑-脊髓接口。
Nature. 2016 Nov 10;539(7628):284-288. doi: 10.1038/nature20118.
8
Challenges in clinical applications of brain computer interfaces in individuals with spinal cord injury.脊髓损伤个体脑机接口临床应用中的挑战。
Front Neuroeng. 2014 Sep 24;7:38. doi: 10.3389/fneng.2014.00038. eCollection 2014.
9
Altering spinal cord excitability enables voluntary movements after chronic complete paralysis in humans.改变脊髓兴奋性可使人在慢性完全瘫痪后进行自主运动。
Brain. 2014 May;137(Pt 5):1394-409. doi: 10.1093/brain/awu038. Epub 2014 Apr 8.
10
High-performance neuroprosthetic control by an individual with tetraplegia.高位截瘫患者的高性能神经假体控制。
Lancet. 2013 Feb 16;381(9866):557-64. doi: 10.1016/S0140-6736(12)61816-9. Epub 2012 Dec 17.