无金属电化学促进的自由基级联环化反应合成含CF的苯并咪唑并[2,1-]异喹啉-6(5)-酮。
Metal-free electrochemistry promoted radical cascade cyclization to access CF-containing benzimidazo[2,1-]isoquinolin-6(5)-ones.
作者信息
Zhang Changjun, Yu Zhichen, Ding Yuxin, Shi Yuan, Xie Yuanyuan
机构信息
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, China.
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, 310014, China.
出版信息
Org Biomol Chem. 2023 Aug 23;21(33):6715-6718. doi: 10.1039/d3ob00854a.
Using CFSONa as the CF radical source, an eco-friendly approach for electrochemistry-mediated radical cascade cyclization of -methacryloyl-2-phenylbenzoimidazoles was described. This reaction features mild reaction conditions, readily available substrates, and moderate to good yields through the construction of two C-C bonds in one step.
以CFSONa作为CF自由基源，描述了一种用于电化学介导的α-甲基丙烯酰基-2-苯基苯并咪唑自由基级联环化的环保方法。该反应具有反应条件温和、底物易于获得的特点，并且通过一步构建两个C-C键可实现中等至良好的产率。
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