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在无金属条件下通过自由基级联环化轻松合成氨基甲酰化苯并咪唑并[2,1-]异喹啉-6(5)-酮

Facile synthesis of carbamoylated benzimidazo[2,1-]isoquinolin-6(5)-ones radical cascade cyclization under metal-free conditions.

作者信息

Liu Qi, Wang Lei, Liu Jie, Ruan Shuchen, Li Pinhua

机构信息

Department of Chemistry, Key Laboratory of Green and Precise Synthetic Chemistry, Ministry of Education, Huaibei Normal University, Huaibei, Anhui 235000, P. R. China.

出版信息

Org Biomol Chem. 2021 Apr 26;19(15):3489-3496. doi: 10.1039/d1ob00101a.

DOI:10.1039/d1ob00101a
PMID:33899870
Abstract

A highly efficient synthesis of carbamoylated benzimidazo[2,1-a]isoquinolin-6(5H)-ones using 2-arylbenzoimidazoles and oxamic acids was developed. This strategy tolerated various substrates as the starting materials to generate the corresponding products in good yields under metal-free conditions.

摘要

利用2-芳基苯并咪唑和草氨酸开发了一种高效合成氨甲酰化苯并咪唑并[2,1-a]异喹啉-6(5H)-酮的方法。该策略可耐受各种底物作为起始原料，在无金属条件下以良好的产率生成相应产物。

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