Department of Chemical Science and Technologies, University of Rome Tor Vergata, 00133, Rome, Italy.
ACS Sens. 2023 Jul 28;8(7):2415-2426. doi: 10.1021/acssensors.3c00564. Epub 2023 Jul 18.
Antibodies are among the most relevant biomolecular targets for diagnostic and clinical applications. In this Perspective, we provide a critical overview of recent research efforts focused on the development and characterization of devices, switches, and reactions based on the use of synthetic antigen-conjugated DNA strands designed to be responsive to specific antibodies. These systems can find applications in sensing, drug-delivery, and antibody-antigen binding characterization. The examples described here demonstrate how the programmability and chemical versatility of synthetic nucleic acids can be used to create innovative analytical tools and target-responsive systems with promising potentials.
抗体是诊断和临床应用中最重要的生物分子靶标之一。在本观点中，我们提供了对最近研究工作的批判性概述，这些工作集中于开发和表征基于使用设计为响应特定抗体的合成抗原缀合 DNA 链的器件、开关和反应。这些系统可应用于传感、药物输送和抗体-抗原结合特性。这里描述的例子表明了如何利用合成核酸的可编程性和化学多功能性来创建具有潜在前景的创新分析工具和靶标响应系统。
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