Laboratory of Biosensors & Nanomachines, Département de Chimie, Université de Montréal, Montréal, Québec H3C 3J7, Canada.
Nanoscale. 2018 Mar 8;10(10):4607-4641. doi: 10.1039/c7nr07348h.
DNA switches are ideally suited for numerous nanotechnological applications, and increasing efforts are being directed toward their engineering. In this review, we discuss how to engineer these switches starting from the selection of a specific DNA-based recognition element, to its adaptation and optimisation into a switch, with applications ranging from sensing to drug delivery, smart materials, molecular transporters, logic gates and others. We provide many examples showcasing their high programmability and recent advances towards their real life applications. We conclude with a short perspective on this exciting emerging field.
DNA 开关非常适合许多纳米技术应用，并且越来越多的人正在致力于它们的工程设计。在这篇综述中，我们讨论了如何从特定的基于 DNA 的识别元件的选择开始，将其适当地优化为开关，从而将其应用于从传感到药物输送、智能材料、分子转运器、逻辑门等各个领域。我们提供了许多例子，展示了它们的高可编程性以及在实际应用中的最新进展。最后，我们对这个令人兴奋的新兴领域进行了简短的展望。
