Centre for Physiotherapy Studies, Faculty of Health Sciences, Universiti Teknologi MARA (UiTM), Bandar Puncak Alam, Malaysia.
Rehabilitation Department, KPJ Bandar Dato' Onn Specialist Hospital, Bandar Dato' Onn, Malaysia.
BMJ Open. 2023 Jul 18;13(7):e068776. doi: 10.1136/bmjopen-2022-068776.
The prevalence of chronic obstructive pulmonary disease (COPD) has been on the rise, with acute exacerbation of COPD associated with the highest burden and multiple pulmonary and systemic consequences. People with COPD have been found to have an abnormal response of systemic inflammation. To date, although limited, there are studies that suggest negative associations between inflammatory markers and important clinical outcomes such as exercise capacity and muscle force. This protocol aims to systematically review the evidence for (i) the associations between inflammatory markers and lung function, muscle force and exercise capacity and (ii) the influence of other factors (eg, hospitalisation, exercise programme) on the level of inflammatory markers in people with COPD.
Scopus, PubMed, Cochrane, Web of Science and ProQuest will be searched from database inception to February 2023 using PEO search strategy (Population: adults with COPD; Exposure: inflammatory markers; Outcomes: lung function, muscle force and exercise capacity). Four reviewers working in pairs will independently screen articles for eligibility and extract data that fulfilled the inclusion criteria. Depending on the design of the included studies, either Cochrane risk-of-bias version 2 or the Newcastle-Ottawa Scale tools will be used to rate the methodological quality of the included studies. Effect sizes reported in each individual study will be standardised to Cohen's d and a random effects model will be used to calculate the pooled effect size for the association.
Ethical approval is unnecessary as this study will only use publicly available data. The findings will be disseminated through publication in peer-reviewed journals and conferences.
CRD42022284446.
慢性阻塞性肺疾病（COPD）的患病率一直在上升，COPD 急性加重与最高负担和多种肺及全身后果相关。已发现 COPD 患者存在全身炎症反应异常。迄今为止，尽管研究有限，但有研究表明炎症标志物与重要的临床结局（如运动能力和肌肉力量）之间存在负相关。本方案旨在系统回顾炎症标志物与肺功能、肌肉力量和运动能力之间的关联证据，以及其他因素（如住院、运动方案）对 COPD 患者炎症标志物水平的影响。
从数据库建立到 2023 年 2 月，将使用 PEO 搜索策略（人群：成人 COPD；暴露：炎症标志物；结局：肺功能、肌肉力量和运动能力）在 Scopus、PubMed、Cochrane、Web of Science 和 ProQuest 上进行搜索。四位审查员将两两合作，独立筛选文章的合格性，并提取符合纳入标准的数据。根据纳入研究的设计，要么使用 Cochrane 偏倚风险 2 版，要么使用纽卡斯尔-渥太华量表工具来评估纳入研究的方法学质量。每个单独研究报告的效应大小将标准化为 Cohen's d，并使用随机效应模型计算关联的汇总效应大小。
由于本研究仅使用公开可用的数据，因此无需获得伦理批准。研究结果将通过发表在同行评议的期刊和会议上进行传播。
PROSPERO 注册号：CRD42022284446。
