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基于集成神经网络的改进SIRD流行病模型参数识别反问题

Inverse problem for parameters identification in a modified SIRD epidemic model using ensemble neural networks.

作者信息

Petrica Marian, Popescu Ionel

机构信息

Faculty of Mathematics and Computer Science, University of Bucharest, Bucharest, Romania.

Gheorghe Mihoc - Caius Iacob Institute of Mathematical Statistics and Applied Mathematics of the Romanian Academy, Bucharest, Romania.

出版信息

BioData Min. 2023 Jul 18;16(1):22. doi: 10.1186/s13040-023-00337-x.

DOI:10.1186/s13040-023-00337-x
PMID:37464258
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10354917/
Abstract

In this paper, we propose a parameter identification methodology of the SIRD model, an extension of the classical SIR model, that considers the deceased as a separate category. In addition, our model includes one parameter which is the ratio between the real total number of infected and the number of infected that were documented in the official statistics. Due to many factors, like governmental decisions, several variants circulating, opening and closing of schools, the typical assumption that the parameters of the model stay constant for long periods of time is not realistic. Thus our objective is to create a method which works for short periods of time. In this scope, we approach the estimation relying on the previous 7 days of data and then use the identified parameters to make predictions. To perform the estimation of the parameters we propose the average of an ensemble of neural networks. Each neural network is constructed based on a database built by solving the SIRD for 7 days, with random parameters. In this way, the networks learn the parameters from the solution of the SIRD model. Lastly we use the ensemble to get estimates of the parameters from the real data of Covid19 in Romania and then we illustrate the predictions for different periods of time, from 10 up to 45 days, for the number of deaths. The main goal was to apply this approach on the analysis of COVID-19 evolution in Romania, but this was also exemplified on other countries like Hungary, Czech Republic and Poland with similar results. The results are backed by a theorem which guarantees that we can recover the parameters of the model from the reported data. We believe this methodology can be used as a general tool for dealing with short term predictions of infectious diseases or in other compartmental models.

摘要

在本文中,我们提出了一种SIRD模型的参数识别方法,该模型是经典SIR模型的扩展,将死亡者视为一个单独的类别。此外,我们的模型包含一个参数,即实际感染总数与官方统计记录的感染数之间的比率。由于许多因素,如政府决策、多种变体传播、学校开学和关闭等,模型参数长时间保持不变的典型假设并不现实。因此,我们的目标是创建一种适用于短时间的方法。在此范围内,我们依靠前7天的数据进行估计,然后使用识别出的参数进行预测。为了进行参数估计,我们提出了一种神经网络集成的平均值。每个神经网络都是基于通过用随机参数求解7天的SIRD构建的数据库构建的。通过这种方式,网络从SIRD模型的解中学习参数。最后,我们使用该集成从罗马尼亚新冠疫情的真实数据中获取参数估计值,然后说明在10天到45天等不同时间段内的死亡人数预测。主要目标是将这种方法应用于罗马尼亚新冠疫情演变的分析,但在匈牙利、捷克共和国和波兰等其他国家也进行了示例,结果类似。结果得到了一个定理的支持,该定理保证我们可以从报告的数据中恢复模型的参数。我们相信这种方法可以用作处理传染病短期预测或其他 compartmental 模型的通用工具。

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