Department of Pharmacy, Vinayaka Missions College of Pharmacy, VMRF (DU), Salem, Tamil Nadu, India.
Department of Pharmaceutical Chemistry, Vinayaka Missions College of Pharmacy, VMRF (DU), Salem, Tamil Nadu, India.
Curr Drug Discov Technol. 2024;21(2):e180723218848. doi: 10.2174/1570163820666230718123544.
Nanoscience and nanotechnology have resulted in the continuous development of new nanomaterials with remarkable properties that make them appealing for pharmaceutical applications. The biocompatibility of metallic nanoparticles is of increasing interest for research scientists currently working towards developing novel nano-based medicines, industrial chemicals, and antigens. There is also a particular interest in using them to counter mutations that up-regulate inflammation enhancers to produce a range of inflammation-related pathologies.
The following review discusses the anti-inflammatory mechanisms of metallic bioconjugated (silver, gold, zinc oxide, titanium dioxide, and selenium) nanoparticles. The current study focuses on nanoparticle manufacturing technologies and the inflammatory response.
A thorough search was conducted in several databases, including Scopus, Embase, Cochrane, and PubMed. The search terms used included: Alzheimer's disease, mechanism of action, neuroinflammation, the reaction of Mast cells to stress and neuroinflammation. The study included all publications published in English.
Green-synthesised nanoparticles can suppress the NF-B and cyclooxygenase-2 pathways, preventing the production of proinflammatory cytokines and ROS scavenging mechanisms. Metallic nanoparticles with anti-inflammatory properties, such as stability and specific targeting, have been briefly discussed.
The current research focuses on metallic nanoparticles employed as anti-inflammatory medication molecules, although nanoparticles have applications in various areas (medicine, chemical engineering, and agriculture). Nanoparticles have a large surface-to-volume ratio, which can help them to penetrate cell membranes, and because of their solid ligand-binding capabilities, nanoparticles have been used in the medical treatment of inflammatory pathologies.
纳米科学和纳米技术不断开发出具有显著性能的新型纳米材料，这些性能使其成为药物应用的理想选择。目前，研究科学家对金属纳米粒子的生物相容性越来越感兴趣，他们致力于开发新型基于纳米的药物、工业化学品和抗原。人们还特别感兴趣的是利用它们来对抗那些上调炎症增强因子的突变，以产生一系列与炎症相关的病理。
以下综述讨论了金属生物共轭（银、金、氧化锌、二氧化钛和硒）纳米粒子的抗炎机制。本研究侧重于纳米粒子制造技术和炎症反应。
在几个数据库（包括 Scopus、Embase、Cochrane 和 PubMed）中进行了全面检索。使用的搜索词包括：阿尔茨海默病、作用机制、神经炎症、肥大细胞对压力和神经炎症的反应。研究包括所有以英文发表的出版物。
绿色合成的纳米粒子可以抑制 NF-B 和环氧化酶-2 途径，防止促炎细胞因子和 ROS 清除机制的产生。简要讨论了具有抗炎特性的金属纳米粒子，如稳定性和特异性靶向。
目前的研究集中在将金属纳米粒子用作抗炎药物分子，尽管纳米粒子在医学、化学工程和农业等各个领域都有应用。纳米粒子具有较大的表面积与体积比，这有助于它们穿透细胞膜，而且由于其固有的配体结合能力，纳米粒子已被用于炎症性病理的医学治疗。
