Centre for Research in Biotechnology for Agriculture, University of Malaya, Kuala Lumpur 50603, Malaysia.
Institute of Biological Sciences (Genetics and Molecular Biology), Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia.
Biomolecules. 2021 Apr 12;11(4):564. doi: 10.3390/biom11040564.
Plants are rich in phytoconstituent biomolecules that served as a good source of medicine. More recently, they have been employed in synthesizing metal/metal oxide nanoparticles (NPs) due to their capping and reducing properties. This green synthesis approach is environmentally friendly and allows the production of the desired NPs in different sizes and shapes by manipulating parameters during the synthesis process. The most commonly used metals and oxides are gold (Au), silver (Ag), and copper (Cu). Among these, Cu is a relatively low-cost metal that is more cost-effective than Au and Ag. In this review, we present an overview and current update of plant-mediated Cu/copper oxide (CuO) NPs, including their synthesis, medicinal applications, and mechanisms. Furthermore, the toxic effects of these NPs and their efficacy compared to commercial NPs are reviewed. This review provides an insight into the potential of developing plant-based Cu/CuO NPs as a therapeutic agent for various diseases in the future.
植物富含植物生源分子生物物质，这些物质是药物的良好来源。最近，由于它们的封闭和还原特性，它们被用于合成金属/金属氧化物纳米粒子（NPs）。这种绿色合成方法对环境友好，并允许通过在合成过程中操纵参数来生产不同尺寸和形状的所需 NPs。最常用的金属和氧化物是金（Au）、银（Ag）和铜（Cu）。在这些金属中，Cu 是一种相对低成本的金属，比 Au 和 Ag 更具成本效益。在这篇综述中，我们介绍了植物介导的 Cu/氧化铜（CuO） NPs 的概述和最新进展，包括它们的合成、药用应用和机制。此外，还综述了这些 NPs 的毒性作用及其与商业 NPs 的疗效比较。这篇综述提供了一个深入了解未来将植物基 Cu/CuO NPs 开发为治疗各种疾病的治疗剂的潜力。
