Abbas Heba Salah, Krishnan Akilandeswari, Kotakonda Muddukrishnaiah
National Organization for Drug Control and Research, Giza, Egypt.
Scientist Under Scheme of Asian Research Training Fellowship-Developing Countries Scientist (RTF-DCS), Federation of Indian Chambers of Commerce and Industry (FICCI), New Delhi, India.
Front Bioeng Biotechnol. 2020 Dec 18;8:595161. doi: 10.3389/fbioe.2020.595161. eCollection 2020.
Green nanotechnology has recently had a significant influence on advances in biological applications. The surface manipulation of iron oxide NPs by zinc oxide is increasing attention for biomedical research. Therefore, this work focused on the phytochemicals of creeper (BM) water extract for synthesizing iron oxide NPs and iron oxide/zinc oxide nanocomposite. The UV spectrum analysis showed a wavelength redshift from 294 to 302 nm of iron oxide/ZnO nanocomposite, and the polydispersity index revealed that the perfect preparations of iron oxide NPs were prepared by boiling 0.25 g of the plant in deionized water then the filtrate added to ferric chloride (1:1 v/v). The HRTEM results also illustrated that amorphous iron oxide NPs are spherical and irregular in shape. However, the iron oxide/ZnO nanocomposite showed a rod shape of ZnO with an average length and width of ∼19.25 ± 3.2 × 3.3 ± 0.6 nm surrounding amorphous iron oxide NPs. Furthermore, a high antimicrobial activity with MRSA and was demonstrated by iron oxide NPs. However, because of instability and negative surface charge of the iron oxide nanocomposite, there was no antimicrobial activity. Future cytotoxic studies of the iron oxide NPs synthesized with polyphenols of BM extract are desirable, and their applications in medical purposes will be recommended.
绿色纳米技术最近对生物应用的进展产生了重大影响。氧化锌对氧化铁纳米颗粒的表面处理在生物医学研究中越来越受到关注。因此，这项工作聚焦于爬山虎（BM）水提取物中的植物化学物质，用于合成氧化铁纳米颗粒和氧化铁/氧化锌纳米复合材料。紫外光谱分析表明，氧化铁/氧化锌纳米复合材料的波长从294纳米红移至302纳米，多分散指数表明，通过将0.25克植物在去离子水中煮沸，然后将滤液加入氯化铁（1:1体积/体积），制备出了完美的氧化铁纳米颗粒。高分辨率透射电子显微镜结果还表明，无定形氧化铁纳米颗粒呈球形且形状不规则。然而，氧化铁/氧化锌纳米复合材料显示出氧化锌的棒状形态，平均长度和宽度约为19.25±3.2×3.3±0.6纳米，围绕着无定形氧化铁纳米颗粒。此外，氧化铁纳米颗粒对耐甲氧西林金黄色葡萄球菌显示出高抗菌活性。然而，由于氧化铁纳米复合材料的不稳定性和负表面电荷，没有抗菌活性。未来对用BM提取物中的多酚合成的氧化铁纳米颗粒进行细胞毒性研究是很有必要的，并且将推荐它们在医学目的中的应用。
