Hu Rui-Si, Zhang Xin, Wei Yanming
Yangtze Delta Region Institute (Quzhou), University of Electronic Science and Technology of China, Quzhou, Zhejiang 324003, China.
Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China.
Bioinform Adv. 2023 Jul 10;3(1):vbad094. doi: 10.1093/bioadv/vbad094. eCollection 2023.
Zoonotic pathogens, such as viruses, bacteria, fungi and parasites, can be transmitted from animals to humans, causing a wide range of diseases that can vary from mild to life-threatening. These pathogens typically exhibit a broad host range, infecting domestic and/or wild animals, which serve as reservoirs of infection. Human infection can occur through direct contact with infected animals or their body fluids, consumption of contaminated food or water, or via bites from infected arthropod vectors. Understanding the epidemiological characteristics and population structure of zoonotic pathogens is of paramount importance for preventing and controlling the spread of zoonotic diseases.
Here, we present ZooPathWeb, a comprehensive online resource for zoonotic pathogens. ZooPathWeb provides essential information on pathogens that are particularly relevant to public health and includes a literature collection organized by pathogen classification, such as lineage, host, country or region and publication year. Moreover, we have developed four web-based utility tools for this release: SeqNHandle, PaPhy-ML, TreeView and BLAST. These tools are specifically designed to facilitate the identification of population structure and adaptive evolution in relation to zoonotic pathogens.
The ZooPathWeb website is accessed via http://lab.malab.cn/~hrs/zoopathweb/. The source code for AKINND, which is used for collecting pathogen-related literature, can be found at https://github.com/RuiSiHu/AKINND. Additionally, the source code for PaPhy-ML, utilized for phylogenetic analysis, can be found at https://github.com/RuiSiHu/PaPhy-ML.
Supplementary data are available at online.
人畜共患病病原体，如病毒、细菌、真菌和寄生虫，可从动物传播给人类，引发一系列从轻度到危及生命的疾病。这些病原体通常具有广泛的宿主范围，感染家畜和/或野生动物，而这些动物充当了感染源。人类感染可通过直接接触受感染动物或其体液、食用受污染的食物或水，或被受感染的节肢动物媒介叮咬而发生。了解人畜共患病病原体的流行病学特征和种群结构对于预防和控制人畜共患病的传播至关重要。
在此，我们展示了ZooPathWeb，这是一个关于人畜共患病病原体的综合在线资源。ZooPathWeb提供了与公共卫生特别相关的病原体的基本信息，并包括一个按病原体分类组织的文献集，如谱系、宿主、国家或地区以及出版年份。此外，我们为此次发布开发了四个基于网络的实用工具：SeqNHandle、PaPhy-ML、TreeView和BLAST。这些工具专门设计用于促进与人畜共患病病原体相关的种群结构和适应性进化的识别。
补充数据可在网上获取。
