Young Holt Bethany, van der Straten Ariane, Barker Taryn, Chirenje Z Mike, Cameron Anne-Isabelle, Scott Cherise, Casas Carmen Pérez, Romano Joseph
CAMI Health, Initiative for MPTs, Public Health Institute, Sacramento, CA, United States.
Center for AIDS Prevention Studies (CAPS), Department of Medicine, UCSF, San Francisco, CA, United States and ASTRA Consulting, Kensington, CA, United States.
Front Reprod Health. 2023 Jul 3;5:1150857. doi: 10.3389/frph.2023.1150857. eCollection 2023.
HIV, other sexually transmitted infections (STIs) and unintended pregnancies are critical and interlinked health risks for millions of women of reproductive age worldwide. Multipurpose prevention technologies (MPTs) offer an innovative approach for expanding combined pregnancy and/or disease prevention. So far, MPT development efforts have focused mostly on HIV prevention, but about half of product candidates comprise compounds active against non-HIV STIs as well. This review aims to provide a framework that promotes the efficient advancement of the most promising preclinical products through the development pathway and into the hands of end-users, with a focus on women in low- and middle-income countries (L/MICs).
This mini review provides a summary of the current landscape of the MPT field. It comprises a landscape assessment of MPTs in development, complemented by a series of 28 in-depth, semi-structured key informant interviews (KIIs) with experts representing different L/MIC perspectives.
We identified six primary action strategies to advance MPTs for L/MICs, including identification of key research gaps and priorities. For each action strategy, progress to date and key recommendations are included.
To realize the life-saving potential of MPTs and maximize the momentum made to date, a strategic, collaborative and well-funded response to the gaps and next steps outlined in this paper is critical. A coordinated response can add rigor and efficiency to the development process, to successfully advance the most promising MPT products to the hands of end-users.
艾滋病毒、其他性传播感染（STIs）和意外怀孕是全球数百万育龄妇女面临的重大且相互关联的健康风险。多功能预防技术（MPTs）为扩大联合预防怀孕和/或疾病提供了一种创新方法。到目前为止，MPT的开发工作主要集中在艾滋病毒预防方面，但约一半的候选产品还包含对非艾滋病毒性传播感染有活性的化合物。本综述旨在提供一个框架，以促进最有前景的临床前产品通过开发途径高效推进并交付给最终用户，重点关注低收入和中等收入国家（L/MICs）的妇女。
本小型综述总结了MPT领域的当前情况。它包括对正在开发的MPT进行的情况评估，并辅以对代表不同L/MIC观点的专家进行的28次深入、半结构化关键信息提供者访谈（KIIs）。
我们确定了六种推进针对L/MICs的MPT的主要行动策略，包括确定关键研究差距和优先事项。对于每种行动策略，都列出了迄今为止的进展情况和关键建议。
为了实现MPT的救命潜力并最大限度地利用迄今为止取得的进展，对本文所述的差距和后续步骤做出战略、协作且资金充足的回应至关重要。协调一致的回应可以为开发过程增添严谨性和效率，从而成功地将最有前景的MPT产品交付给最终用户。
