RTI International, Berkeley, USA.
Women's Global Health Imperative, RTI International, 2150 Shattuck Avenue, Suite 800, Berkeley, CA, 94704, USA.
AIDS Behav. 2022 Dec;26(12):3848-3861. doi: 10.1007/s10461-022-03713-6.
End-user input early in biomedical product development may optimize design to support high uptake and adherence. We interviewed 400 couples (800 total participants) in Uganda and Zimbabwe to assess their preferences for multipurpose prevention technologies (MPTs) for HIV and pregnancy prevention. Using a discrete choice experiment, couples made a series of choices between hypothetical MPTs, including oral tablets and vaginal rings, inserts, and films and completed an interviewer-administered questionnaire assessing sociodemographic and behavioral measures. Most couples preferred presented MPTs over male condoms. Couples' MPT choices in both countries were influenced most by the combination of product form and dosing frequency, with monthly dosing preferred over daily. Analysis highlighted differences by country as to which side effects were most important: Ugandan couples placed greater importance on effects on the vaginal environment during sex, whereas Zimbabwean couples placed more importance on changes to menstruation and other side effects (headache, cramps). Couples' preferences signaled an openness to new product forms and more frequent dosing if preferred characteristics of other attributes were achieved.
在生物医药产品开发的早期，终端用户的输入可能会优化设计，以支持高采用率和高依从性。我们在乌干达和津巴布韦采访了 400 对夫妇（共计 800 名参与者），评估他们对用于艾滋病毒和妊娠预防的多种用途预防技术（MPT）的偏好。研究人员采用离散选择实验，让夫妇在一系列假设的 MPT 之间做出选择，包括口服片剂和阴道环、插入物以及薄膜，并完成了由访谈者管理的调查问卷，评估社会人口统计学和行为措施。大多数夫妇更喜欢 MPT 而不是男用避孕套。两国夫妇对 MPT 的选择受产品形式和给药频率的组合影响最大，每月给药比每日给药更受欢迎。分析突出了国家之间的差异，即哪些副作用最重要：乌干达夫妇在性行为期间更关注阴道环境的影响，而津巴布韦夫妇则更关注月经和其他副作用（头痛、痉挛）的变化。如果能达到其他属性的首选特征，夫妇的偏好表明他们愿意接受新产品形式和更频繁的给药。
