Hosak Ladislav, Sadykov Evgenii, Zapletalova Jana, Hosakova Jirina, Stepanov Alexandr, Latalova Klara, Masopust Jiri, Sery Omar, Studnicka Jan
Department of Psychiatry, University Hospital Hradec Kralove and Charles University, Faculty of Medicine in Hradec Kralove, Czech Republic.
Department of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic.
Neuro Endocrinol Lett. 2023 Jul 28;44(5):290-296.
Studies of schizophrenia endophenotypes may help clinicians better understand the etiopathogenesis and treatment of this mental disorder. The aim of the study was to determine if retinal arteriolar or venular abnormalities are an endophenotype of schizophrenia.
We performed a one-time cross-sectional study.
We enlisted schizophrenic patients (n = 53) hospitalized in the Department of Psychiatry, University Hospital Hradec Kralove; their mentally healthy first-degree relatives (n = 53); and unrelated, age- and sex-matched mentally healthy controls (n = 49). We recorded all participants´ sociodemographic and, if relevant, clinical variables. Retinal imaging was carried out using a digital fundus camera (FF450 + IR). Outcomes included retinal vessel calibers measured using the software application VAMPIRE.
The study enrolled fifty-three schizophrenic patients (average age 32.1 years; males n = 38), an equal number of healthy relatives (average age 47.3 years; males n = 18), and forty-nine unrelated healthy controls (average age 32.2 years; males n = 35). Patients with schizophrenia had significantly increased retinal arteriolar diameters when compared to unrelated healthy controls (left eye p = 0.003; right eye p = 0.011) but not when compared to healthy relatives. The sizes of the retinal venules were not significantly different among the study groups.
Our cross-sectional findings do not support the notion that retinal microvascular anomalies are an endophenotype in schizophrenia. Longitudinal studies of this subject should be included in further research.
对精神分裂症内表型的研究可能有助于临床医生更好地理解这种精神障碍的病因和治疗方法。本研究的目的是确定视网膜小动脉或小静脉异常是否为精神分裂症的一种内表型。
我们进行了一项一次性横断面研究。
我们招募了在赫拉德茨克拉洛韦大学医院精神病科住院的精神分裂症患者（n = 53）；他们心理健康的一级亲属（n = 53）；以及年龄和性别匹配的无血缘关系的心理健康对照者（n = 49）。我们记录了所有参与者的社会人口学信息以及（如相关）临床变量。使用数码眼底相机（FF450 + IR）进行视网膜成像。结果包括使用软件应用程序VAMPIRE测量的视网膜血管口径。
该研究纳入了53名精神分裂症患者（平均年龄32.1岁；男性n = 38）、数量相等的健康亲属（平均年龄47.3岁；男性n = 18）以及49名无血缘关系的健康对照者（平均年龄32.2岁；男性n = 35）。与无血缘关系的健康对照者相比，精神分裂症患者的视网膜小动脉直径显著增加（左眼p = 0.003；右眼p = 0.011），但与健康亲属相比则无显著差异。各研究组之间视网膜小静脉的大小无显著差异。
我们的横断面研究结果不支持视网膜微血管异常是精神分裂症内表型这一观点。该主题的纵向研究应纳入进一步的研究中。
