美国按种族和民族、年龄和性别划分的确诊白癜风发病率和患病率。

Incidence and Prevalence of Diagnosed Vitiligo According to Race and Ethnicity, Age, and Sex in the US.

机构信息

Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York.

出版信息

JAMA Dermatol. 2023 Sep 1;159(9):986-990. doi: 10.1001/jamadermatol.2023.2162.

DOI:10.1001/jamadermatol.2023.2162

PMID:37466934

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10357354/

Abstract

IMPORTANCE

Vitiligo has substantial psychosocial consequences. Yet its burden is poorly established.

OBJECTIVE

To estimate incidence and prevalence of diagnosed vitiligo across age, sex, and racial and ethnic subgroups in the US.

DESIGN, SETTING, AND PARTICIPANTS: This analysis comprising a cohort study and cross-sectional study included electronic health records for health care-seeking children, adolescents, and adults across 4 US census regions. Data for the incidence analysis were obtained from January 1, 2015, through December 31, 2019, and data for the prevalence analysis were obtained from January 1 through December 31, 2019. Data were analyzed from December 13, 2022, to June 8, 2023.

MAIN OUTCOMES AND MEASURES

The main outcomes were incidence (per 100 000 person-years [PY]) and prevalence of diagnosed vitiligo overall and by age, race and ethnicity, and sex.

RESULTS

A total of 2 980 778 patients with vitiligo were included in the incidence analysis (mean [SD] age, 41.5 [24.0] years; 57.0% female; 1.4% Asian American; 12.9% Black; 1.5% Hispanic/Latino; 77.3% White; 6.9% other or multiracial) and 1 057 534 in the prevalence analysis (mean [SD] age, 43.4 [24.7] years; 57.5% female; 1.7% Asian American, 14.7% Black, 1.4% Hispanic/Latino; 75.7% White; 6.6% other or multiracial). Age- and sex-adjusted overall incidence rate (IR) of diagnosed vitiligo was 22.6 per 100 000 PY (95% CI, 21.5-23.8 per 100 000 PY), and prevalence was 0.16% (95% CI, 0.15%-0.17%). Sex-adjusted IR was highest among patients aged 60 to 69 years (25.3 per 100 000 PY; 95% CI, 22.2-28.6 per 100 000 PY), and prevalence was highest among patients aged 70 years or older (0.21%; 95% CI, 0.19%-0.23%). The highest age-adjusted IR was observed among Asian American patients (41.2 per 100 000 PY; 95% CI, 28.2-58.2 per 100 000 PY), followed by Hispanic/Latino patients (37.3 per 100 000 PY; 95% CI, 25.7-52.4 per 100 000 PY), patients reporting other or multiple races (31.1 per 100 000 PY; 95% CI, 25.9-37.1 per 100 000 PY), Black patients (29.6 per 100 000 PY; 95% CI, 26.0-33.6 per 100 000 PY), and White patients (18.7 per 100 000 PY; 95% CI, 17.5-20.0 per 100 000 PY). The highest age-adjusted prevalence was observed among Hispanic/Latino patients (0.29%; 95% CI, 0.20%-0.39%), followed by Asian American patients (0.27%; 95% CI, 0.19%-0.35%), patients reporting other or multiple races (0.24%; 95% CI, 0.20%-0.28%), Black patients (0.22%; 95% CI, 0.19%-0.24%), and White patients (0.13%; 95% CI, 0.12%-0.14%).

CONCLUSIONS AND RELEVANCE

This cross-sectional study found that vitiligo diagnosis was more common in older patients, Hispanic/Latino patients, and Asian American patients.

摘要

重要性

白癜风有很大的心理社会后果。然而，其负担尚未得到充分确立。

目的

估计美国不同年龄、性别和种族及族裔亚组中已确诊白癜风的发病率和患病率。

设计、设置和参与者：本分析包括一项队列研究和一项横断面研究，纳入了来自美国 4 个人口普查区的寻求医疗保健的儿童、青少年和成年人的电子健康记录。发病率分析的数据来自 2015 年 1 月 1 日至 2019 年 12 月 31 日，患病率分析的数据来自 2019 年 1 月 1 日至 12 月 31 日。数据分析于 2023 年 6 月 8 日从 12 月 13 日开始进行。

主要结局和措施

主要结局是总体诊断为白癜风的发病率（每 100000 人年[PY]的发生率）和患病率，以及按年龄、种族和族裔以及性别进行分层的发病率和患病率。

结果

在发病率分析中，共纳入了 2980778 例白癜风患者（平均[SD]年龄，41.5[24.0]岁；57.0%为女性；1.4%为亚裔美国人；12.9%为黑人；1.5%为西班牙裔/拉丁裔；77.3%为白人；6.9%为其他或多种族裔），在患病率分析中纳入了 1057534 例患者（平均[SD]年龄，43.4[24.7]岁；57.5%为女性；1.7%为亚裔美国人，14.7%为黑人，1.4%为西班牙裔/拉丁裔；75.7%为白人；6.6%为其他或多种族裔）。经年龄和性别调整的诊断性白癜风总体发病率（IR）为 22.6/100000PY（95%CI，21.5-23.8/100000PY），患病率为 0.16%（95%CI，0.15%-0.17%）。60 至 69 岁年龄组的性别调整发病率（IR）最高（25.3/100000PY；95%CI，22.2-28.6/100000PY），70 岁及以上年龄组的患病率最高（0.21%；95%CI，0.19%-0.23%）。亚裔美国人患者的年龄调整发病率最高（41.2/100000PY；95%CI，28.2-58.2/100000PY），其次是西班牙裔/拉丁裔患者（37.3/100000PY；95%CI，25.7-52.4/100000PY）、报告其他或多种族裔的患者（31.1/100000PY；95%CI，25.9-37.1/100000PY）、黑人患者（29.6/100000PY；95%CI，26.0-33.6/100000PY）和白人患者（18.7/100000PY；95%CI，17.5-20.0/100000PY）。西班牙裔/拉丁裔患者的年龄调整患病率最高（0.29%；95%CI，0.20%-0.39%），其次是亚裔美国人患者（0.27%；95%CI，0.19%-0.35%）、报告其他或多种族裔的患者（0.24%；95%CI，0.20%-0.28%）、黑人患者（0.22%；95%CI，0.19%-0.24%）和白人患者（0.13%；95%CI，0.12%-0.14%）。