Allen-Mersh T G, Wilson E J, Hope-Stone H F, Mann C V
J R Soc Med. 1986 Jul;79(7):387-90. doi: 10.1177/014107688607900704.
Radiation-induced bowel damage occurred in 4.3% of patients treated primarily by irradiation for uterine carcinoma during the period 1962-1982. There has been a progressive rise in the incidence of radiation damage and radiation-induced rectovaginal fistula during this 20-year period. Radiation from intracavitary sources was a contributory factor in 92% of injured cases. The rising incidence of bowel damage in our patients may be due to an increase in the number of patients receiving a high rectal dose from the intracavitary source. There was a significantly (P less than 0.01) higher incidence of radiation injury in cases of cervical carcinoma compared to endometrial carcinoma. This was because cervical carcinoma tended to present at a more advanced stage than endometrial carcinoma and was more frequently treated with combined external and intracavitary irradiation. There was no significant increase in the incidence of complications among patients undergoing hysterectomy.
1962年至1982年期间，主要接受放射治疗的子宫癌患者中，4.3%发生了放射性肠损伤。在这20年期间，放射损伤和放射性直肠阴道瘘的发生率呈逐渐上升趋势。腔内放射源导致的放射在92%的损伤病例中起了作用。我们的患者中肠损伤发生率上升可能是由于接受腔内放射源高直肠剂量的患者数量增加。与子宫内膜癌相比，宫颈癌患者的放射损伤发生率显著更高（P小于0.01）。这是因为宫颈癌往往比子宫内膜癌处于更晚期，且更常接受外照射和腔内照射联合治疗。接受子宫切除术的患者并发症发生率没有显著增加。
