Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York.
Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York
J Pharmacol Exp Ther. 2023 Oct;387(1):100-110. doi: 10.1124/jpet.122.001538. Epub 2023 Jul 19.
Ras-GTPase-activating protein (SH3 domain)-binding proteins (G3BP) are RNA binding proteins that play a critical role in stress granule (SG) formation. SGs protect critical mRNAs from various environmental stress conditions by regulating mRNA stability and translation to maintain regulated gene expression. Recent evidence suggests that G3BPs can also regulate mRNA expression through interactions with RNA outside of SGs. G3BPs have been associated with a number of disease states, including cancer progression, invasion, metastasis, and viral infections, and may be useful as a cancer therapeutic target. This review summarizes the biology of G3BP including their structure, function, localization, role in cancer progression, virus replication, mRNA stability, and SG formation. We will also discuss the potential of G3BPs as a therapeutic target. SIGNIFICANCE STATEMENT: This review will discuss the molecular mechanism(s) and functional role(s) of Ras-GTPase-activating protein (SH3 domain)-binding proteins in the context of stress granule formation, interaction with viruses, stability of RNA, and tumorigenesis.
Ras-GTPase-activating protein (SH3 domain)-binding proteins (G3BP) 是 RNA 结合蛋白，在应激颗粒 (SG) 的形成中发挥着关键作用。SG 通过调节 mRNA 的稳定性和翻译来保护关键的 mRNAs 免受各种环境应激条件的影响，从而维持受调控的基因表达。最近的证据表明，G3BPs 还可以通过与 SG 外的 RNA 相互作用来调节 mRNA 表达。G3BPs 与多种疾病状态有关，包括癌症进展、侵袭、转移和病毒感染，并且可能是癌症治疗的一个有价值的靶点。这篇综述总结了 G3BP 的生物学特性，包括其结构、功能、定位、在癌症进展、病毒复制、mRNA 稳定性和 SG 形成中的作用。我们还将讨论 G3BPs 作为治疗靶点的潜力。
本综述将讨论 Ras-GTPase-activating protein (SH3 domain)-binding proteins 在应激颗粒形成、与病毒相互作用、RNA 稳定性和肿瘤发生等方面的分子机制和功能作用。
