State Key Laboratory of Veterinary Etiological Biology and OIE/National Foot and Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Front Immunol. 2021 Aug 30;12:718548. doi: 10.3389/fimmu.2021.718548. eCollection 2021.
Ras-GTPase-activating protein (SH3 domain)-binding protein (G3BP) is an RNA binding protein. G3BP is a key component of stress granules (SGs) and can interact with many host proteins to regulate the expression of SGs. As an antiviral factor, G3BP can interact with viral proteins to regulate the assembly of SGs and thus exert antiviral effects. However, many viruses can also use G3BP as a proximal factor and recruit translation initiation factors to promote viral proliferation. G3BP regulates mRNA translation and attenuation to regulate gene expression; therefore, it is closely related to diseases, such as cancer, embryonic death, arteriosclerosis, and neurodevelopmental disorders. This review discusses the important discoveries and developments related G3BP in the biological field over the past 20 years, which includes the formation of SGs, interaction with viruses, stability of RNA, and disease progression.
Ras-GTPase-activating protein (SH3 domain)-binding protein (G3BP) 是一种 RNA 结合蛋白。G3BP 是应激颗粒 (SGs) 的关键组成部分，可与许多宿主蛋白相互作用，调节 SGs 的表达。作为一种抗病毒因子，G3BP 可与病毒蛋白相互作用，调节 SGs 的组装，从而发挥抗病毒作用。然而，许多病毒也可以利用 G3BP 作为近端因子，并招募翻译起始因子来促进病毒增殖。G3BP 调节 mRNA 翻译和衰减以调节基因表达；因此，它与疾病密切相关，如癌症、胚胎死亡、动脉粥样硬化和神经发育障碍。本综述讨论了过去 20 年来与 G3BP 相关的生物学领域的重要发现和进展，包括 SGs 的形成、与病毒的相互作用、RNA 的稳定性以及疾病的进展。
