Federal University of Paraíba, Health Sci. Center, 50670-910, João Pessoa, PB, Brazil.
Graduate of the Postgraduate Program in Natural and Synthetic Bioactive Products - Federal University of Paraíba, João Pessoa, PB, Brazil.
Curr Drug Targets. 2023;24(10):797-815. doi: 10.2174/1389450124666230719105849.
Skin aging is a natural process resulting from intrinsic (hormonal and genetic) and extrinsic (environmental) factors. Photoaging occurs due to prolonged exposure of the skin to ultraviolet radiation, accounting for 80% of facial aging.
Characteristics of aging skin include reduced elasticity, the appearance of fine wrinkles, uneven tone, and dryness. Clinical signs of photoaging involve the presence of deeper wrinkles, rough texture, dyschromia and a greater loss of elasticity compared to chronological aging.
This work reported several scientific articles that used computational techniques, such as molecular docking, molecular dynamics and quantitative structure-activity relationship (QSAR) to identify natural products and their derivatives against skin aging and photoaging.
The in silico analyses carried out by the researchers predicted the binding affinity and interactions of the natural products with the targets matrix metalloproteinase-1, matrix metalloproteinase- 3, matrix metalloproteinase-9 and tyrosinase. Furthermore, some studies have reported the stability of the protein-ligand complex and the physicochemical properties of the studied compounds. Finally, this research proposes promising molecules against the targets.
Thus, studies like this one are relevant to guide new research related to skin aging and photoaging.
皮肤衰老源于内在（激素和遗传）和外在（环境）因素的自然过程。光老化是由于皮肤长时间暴露在紫外线下引起的，占面部衰老的 80%。
衰老皮肤的特征包括弹性降低、出现细小皱纹、肤色不均和干燥。与自然衰老相比，光老化的临床迹象包括更深的皱纹、粗糙的纹理、色素沉着不均以及弹性丧失更大。
本工作报道了几项使用计算技术（如分子对接、分子动力学和定量构效关系（QSAR））来识别天然产物及其衍生物以对抗皮肤衰老和光老化的科学文章。
研究人员进行的计算机分析预测了天然产物与基质金属蛋白酶-1、基质金属蛋白酶-3、基质金属蛋白酶-9 和酪氨酸酶等靶标的结合亲和力和相互作用。此外，一些研究报告了蛋白-配体复合物的稳定性和所研究化合物的物理化学性质。最后，本研究提出了针对这些靶点的有前途的分子。
因此，像这样的研究对于指导与皮肤衰老和光老化相关的新研究具有重要意义。
