Department of Chemistry, University College of Science, Saifabad, Osmania University, Hyderabad, Telangana - 500004, India.
Molecular Modelling Research Laboratory, Department of Chemistry, Osmania University, Hyderabad, Telangana - 500007, India.
Curr Drug Targets. 2023;24(10):790-796. doi: 10.2174/1389450124666230719102112.
Cancer is a complex disease that develops when abnormal cells divide uncontrollably as a consequence of unregulated cell cycle protein activity. Therefore, the cell cycle is crucial for maintaining homeostasis inside the cells during DNA replication and cell division. The presence of mutations within specific genes can disrupt the equilibrium within cells, ultimately leading to the growth of cancer. CDK20 (Cyclin-Dependent Kinase 20) is recently identified as a major controller of cell cycle checkpoints, which regulate cell growth and proliferation and perform a role in the development of many malignancies. CCRK (Cell-Cycle Related Kinase) has recently been renamed CDK20. Emerging studies proclaimed that the upregulation of CDK20 was identified in cancers of the ovary, brain, colon, stomach, liver, and lung. CDK20 was thought to have Cyclin-dependent activating kinase (CAK) activity for CDK2 when it is complexed with Cyclin H. Furthermore, recent studies revealed that CDK20 is involved in the Wnt, EZH2/NF-B, and KEAP1-NRF2 signaling pathways, all of which are interconnected to cancer formation and proliferation. In addition, the structure of CDK20 was predicted using ColabFold, a powerful software integrating AlphaFold's advanced AI system. The present review focuses on a systematic overview of the current knowledge on CDK20 derived from and studies and emphasizes its role in carcinogenesis. The validation comparison of the existing CDK20 AlphaFold structure with the ColabFold was found to be exceptionally fast and accurate in generating reliable models.
癌症是一种复杂的疾病，当细胞周期蛋白活性不受控制地分裂时，就会发生异常细胞的无节制分裂。因此，细胞周期对于在 DNA 复制和细胞分裂过程中维持细胞内的平衡至关重要。特定基因内的突变会破坏细胞内的平衡，最终导致癌症的生长。CDK20（细胞周期蛋白依赖性激酶 20）最近被确定为细胞周期检查点的主要控制器，它调节细胞生长和增殖，并在许多恶性肿瘤的发展中发挥作用。CCRK（细胞周期相关激酶）最近已更名为 CDK20。新的研究宣称，CDK20 的上调在卵巢癌、脑癌、结肠癌、胃癌、肝癌和肺癌中被发现。当 CDK20 与 Cyclin H 形成复合物时，它被认为具有 Cyclin 依赖性激活激酶（CAK）活性。此外，最近的研究表明，CDK20 参与了 Wnt、EZH2/NF-B 和 KEAP1-NRF2 信号通路，所有这些通路都与癌症的形成和增殖相互关联。此外，使用 ColabFold 预测了 CDK20 的结构，ColabFold 是一款集成了 AlphaFold 先进人工智能系统的强大软件。本综述重点介绍了从和研究中获得的关于 CDK20 的现有知识的系统概述，并强调了其在致癌作用中的作用。现有的 CDK20 AlphaFold 结构与 ColabFold 的验证比较发现，生成可靠模型的速度非常快且准确。
