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载 X 射线和磁共振对比剂的纳米颗粒增强影像引导放射治疗口腔癌的疗效。

X-ray and MR Contrast Bearing Nanoparticles Enhance the Therapeutic Response of Image-Guided Radiation Therapy for Oral Cancer.

机构信息

Centre for Medical Biotechnology, Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, India.

Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, USA.

出版信息

Technol Cancer Res Treat. 2023 Jan-Dec;22:15330338231189593. doi: 10.1177/15330338231189593.

DOI:10.1177/15330338231189593
PMID:37469184
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10363893/
Abstract

INTRODUCTION

Radiation therapy for head and neck squamous cell carcinoma is constrained by radiotoxicity to normal tissue. We demonstrate 100 nm theranostic nanoparticles for image-guided radiation therapy planning and enhancement in rat head and neck squamous cell carcinoma models.

METHODS

PEG conjugated theranostic nanoparticles comprising of Au nanorods coated with Gadolinium oxide layers were tested for radiation therapy enhancement in 2D cultures of OSC-19-GFP-luc cells, and orthotopic tongue xenografts in male immunocompromised Salt sensitive or SS rats via both intratumoral and intravenous delivery. The radiation therapy enhancement mechanism was investigated.

RESULTS

Theranostic nanoparticles demonstrated both X-ray/magnetic resonance contrast in a dose-dependent manner. Magnetic resonance images depicted optimal tumor-to-background uptake at 4 h post injection. Theranostic nanoparticle + Radiation treated rats experienced reduced tumor growth compared to controls, and reduction in lung metastasis.

CONCLUSIONS

Theranostic nanoparticles enable preprocedure radiotherapy planning, as well as enhance radiation treatment efficacy for head and neck tumors.

摘要

简介

头颈部鳞状细胞癌的放射治疗受到正常组织放射性毒性的限制。我们展示了用于头颈部鳞状细胞癌模型的图像引导放射治疗计划和增强的 100nm 治疗诊断纳米颗粒。

方法

聚乙二醇修饰的治疗诊断纳米颗粒由金纳米棒组成，表面涂有氧化钆层，用于测试 2D 培养的 OSC-19-GFP-luc 细胞和雄性免疫缺陷盐敏感或 SS 大鼠的原位舌异种移植物的放射治疗增强作用，通过瘤内和静脉内给药。研究了放射治疗增强的机制。

结果

治疗诊断纳米颗粒具有 X 射线/磁共振对比的剂量依赖性。磁共振图像显示，在注射后 4 小时，肿瘤与背景的摄取达到最佳。与对照组相比，治疗诊断纳米颗粒+放射治疗的大鼠肿瘤生长减少，肺转移减少。

结论

治疗诊断纳米颗粒能够进行术前放射治疗计划，并增强头颈部肿瘤的放射治疗效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c35/10363893/46258a73b025/10.1177_15330338231189593-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c35/10363893/173b6eeec382/10.1177_15330338231189593-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c35/10363893/7c82b1d1b732/10.1177_15330338231189593-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c35/10363893/b925a770bb47/10.1177_15330338231189593-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c35/10363893/acf06127c816/10.1177_15330338231189593-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c35/10363893/577cf048368e/10.1177_15330338231189593-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c35/10363893/1b4df77336fa/10.1177_15330338231189593-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c35/10363893/46258a73b025/10.1177_15330338231189593-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c35/10363893/173b6eeec382/10.1177_15330338231189593-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c35/10363893/7c82b1d1b732/10.1177_15330338231189593-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c35/10363893/b925a770bb47/10.1177_15330338231189593-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c35/10363893/acf06127c816/10.1177_15330338231189593-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c35/10363893/577cf048368e/10.1177_15330338231189593-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c35/10363893/1b4df77336fa/10.1177_15330338231189593-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c35/10363893/46258a73b025/10.1177_15330338231189593-fig7.jpg

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