Sanghuachang Wiyakarn, Hengudomsub Pornpat, Chaimongkol Nujjaree, Kotchabhakdi Naiphinich
Faculty of Nursing, Burapha University, Chon Buri, Thailand.
Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Salaya, Nakhon Pathom, Thailand.
Belitung Nurs J. 2023 Apr 18;9(2):100-109. doi: 10.33546/bnj.2476. eCollection 2023.
Mild cognitive impairment (MCI) is an early stage of cognitive decline in individuals who are still able to perform their activities of daily living. They are at increased risk of developing dementia. Improving and maintaining cognitive functions are essential goals for older people with MCI to delay or prevent the transition to dementia.
This study investigated the effect of the neurobic exercise program on memory performance among community-dwelling older adults with MCI.
A single-blind, randomized, controlled, two-period crossover design was used. Thirty-two older adults who met the study criteria were randomly assigned to one of two sequence groups, A ( =16) and B ( = 16). Group A received three weeks of neurobic exercise, followed by a three-week washout period, and then three weeks of the traditional brain exercise program. Group B received the treatments in the reverse order but otherwise in a similar manner. Two aspects of memory performance were evaluated: subjective memory and objective memory. Blinded evaluators measured the outcomes four times at baseline, post-intervention (week 3), follow-up stage (week 7), and the end of the study (week 9). Descriptive statistics, independent -tests, and repeated measures ANOVA were employed for data analyses.
For subjective memory, rmANOVA revealed a significant difference of within-subject (F = 9.324, <0.05) and interaction effect (timegroup) (F, = 12.313, <0.05) and also showed significant differences of within-subject (F = 28.931, < .05) and interaction effect (timegroup) (F = 31.190, <0.05) for objective memory. The study results revealed that the participants in both groups had significantly lower mean scores on the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE), indicating better or improved subjective memory. They also had significantly higher mean scores on the Common Objects Memory Test (COMT) after receiving the neurobic exercise program, indicating improvement in cognitive performance.
The neurobic exercise intervention could improve subjective and objective memory among community-dwelling older adults with MCI more than those who received the traditional brain exercise program. Therefore, the neurobic exercise program can be used by nurses and multidisciplinary teams to enhance memory performance among older adults with MCI.
Thai Clinical Trials Registry (TCTR) 20210326003.
轻度认知障碍（MCI）是认知功能下降的早期阶段，患者仍能够进行日常生活活动。他们患痴呆症的风险增加。改善和维持认知功能是患有MCI的老年人延迟或预防向痴呆症转变的重要目标。
本研究调查了健脑运动计划对社区居住的患有MCI的老年人记忆表现的影响。
采用单盲、随机、对照、两阶段交叉设计。32名符合研究标准的老年人被随机分配到两个序列组中的一组，A组（n = 16）和B组（n = 16）。A组接受为期三周的健脑运动，随后是为期三周的洗脱期，然后是为期三周的传统脑力锻炼计划。B组按相反顺序接受治疗，但方式相似。评估了记忆表现的两个方面：主观记忆和客观记忆。盲法评估者在基线、干预后（第3周）、随访阶段（第7周）和研究结束时（第9周）对结果进行了四次测量。采用描述性统计、独立样本t检验和重复测量方差分析进行数据分析。
对于主观记忆，重复测量方差分析显示，组内存在显著差异（F = 9.324，P < 0.05）和交互效应（时间组）（F，df = 12.313，P < 0.05）；对于客观记忆，组内也存在显著差异（F = 28.931，P <.05）和交互效应（时间组）（F = 31.190，P < 0.05）。研究结果显示，两组参与者在老年人认知衰退知情者问卷（IQCODE）上的平均得分显著较低，表明主观记忆更好或有所改善。在接受健脑运动计划后，他们在普通物体记忆测试（COMT）上的平均得分也显著较高，表明认知表现有所改善。
与接受传统脑力锻炼计划的人相比，健脑运动干预可以更有效地改善社区居住的患有MCI的老年人的主观和客观记忆。因此，护士和多学科团队可以采用健脑运动计划来提高患有MCI的老年人的记忆表现。
泰国临床试验注册中心（TCTR）20210326003。
