Graduate School, Capital University of Physical Education and Sports, Beijing, China.
Encephalopathy Center, Beijing Hospital of Integrated Traditional Chinese and Western Medicine, Beijing, China.
Am J Alzheimers Dis Other Demen. 2023 Jan-Dec;38:15333175231190626. doi: 10.1177/15333175231190626.
To examine the effect of combination exercise program on cognitive function of older adults with mild cognitive impairment (MCI), and identify biomarkers associated with improvement of cognitive functions.
Subjects were 42 older adults (ages, 60-80 years) with MCI. The subjects were randomly classified to traditional Chinese exercise combined with rhythm training group (TCE + RTG, n = 14), walking group (WG, n = 14), and control group (CG, n = 14), according to their level of MMSE scores. These groups exercised for 60 minutes at 1 session, 3 sessions a week for 12 weeks. The intervention program was conducted under multitask conditions to stimulate attention and memory, and the control group attended 3 education classes. Measurements were administered before, after the 6-week, and after the 12-week intervention period; Measurements: The Mini-mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Symbol Digit Modalities Test (SDMT), Activities of Daily Living Scale (ADL), and the 17-item Hamilton Depression Scale (HAMD-17), along with the brain-derived neurotrophic factor (BDNF). A repeated-measures analysis of variance was used to examine differences among the 3 groups and between the 3 testing times (pre-test vs middle-test vs post-test).
(1) The TCE + RTG showed significant improvement in the MMSE, MoCA, SDMT, and ADL scale test results ( < .01) and HAMD-17 scale test results ( < .05). The WG also showed significant improvement in the MMSE, MoCA, and HAMD-17 scale test results ( < .05) and the ADL scale test results ( < .01). While there was no significant change in the CG after the intervention. (2) The TCE + RTG and WG showed positive improvement in peripheral blood BDNF levels, while the CG showed a decrease in these test results. There were significant differences between the TCE + RTG and CG before and after the intervention.
The results suggested that a TCE + RT is beneficial for improving memory and maintaining general cognitive function and peripheral blood BDNF levels in older adults with MCI. Peripheral blood BDNF levels may predict improvement of cognitive functions in older adults with MCI. Further studies are required to determine the positive effects of TCE + RT on cognitive function in older adults with MCI. Trial Registration: ChiCTR2200058545, Registered 10 April 2022.
本研究旨在探讨组合运动方案对轻度认知障碍（MCI）老年人认知功能的影响，并确定与认知功能改善相关的生物标志物。
本研究共纳入 42 名年龄在 60-80 岁的 MCI 老年人。根据简易精神状态检查表（MMSE）评分，将受试者随机分为传统中医结合节奏训练组（TCE + RTG，n = 14）、步行组（WG，n = 14）和对照组（CG，n = 14）。这些组以 1 次/ session、3 次/周的频率进行 60 分钟的运动，共持续 12 周。干预方案在多任务条件下进行，以刺激注意力和记忆力，对照组则参加 3 次教育课程。在干预前、第 6 周和第 12 周后进行测量；测量：简易精神状态检查表（MMSE）、蒙特利尔认知评估（MoCA）、符号数字模态测验（SDMT）、日常生活活动量表（ADL）和 17 项汉密尔顿抑郁量表（HAMD-17），以及脑源性神经营养因子（BDNF）。采用重复测量方差分析比较 3 组间和 3 个测试时间点（前测、中测、后测）的差异。
（1）TCE + RTG 组在 MMSE、MoCA、SDMT 和 ADL 量表测试结果（ <.01）和 HAMD-17 量表测试结果（ <.05）方面均有显著改善。WG 组在 MMSE、MoCA 和 HAMD-17 量表测试结果（ <.05）和 ADL 量表测试结果（ <.01）方面也有显著改善。而 CG 组在干预后无显著变化。（2）TCE + RTG 和 WG 组外周血 BDNF 水平呈阳性改善，而 CG 组则呈下降趋势。TCE + RTG 和 CG 组干预前后差异有统计学意义。
结果表明，TCE + RT 对改善 MCI 老年人的记忆力和维持一般认知功能以及外周血 BDNF 水平有益。外周血 BDNF 水平可能预测 MCI 老年人认知功能的改善。还需要进一步研究来确定 TCE + RT 对 MCI 老年人认知功能的积极影响。
ChiCTR2200058545，于 2022 年 4 月 10 日注册。
