针对轻度认知障碍（MCI）或轻度痴呆的老年人，进行达克罗兹韵律操和简单家庭锻炼计划的安全性与可行性：“为您的大脑行动”试点试验

Safety and feasibility of a Dalcroze eurhythmics and a simple home exercise program among older adults with mild cognitive impairment (MCI) or mild dementia: the MOVE for your MIND pilot trial.

作者信息

Fischbacher Melanie, Chocano-Bedoya Patricia Orializ, Meyer Ursina, Bopp Irene, Mattle Michèle, Kressig Reto Werner, Egli Andreas, Bischoff-Ferrari Heike Annette

机构信息

Department of Geriatrics, University Hospital Zurich, Rämistrasse 100, 8091 Zürich, Switzerland.

Center on Aging and Mobility, University Hospital Zurich, Waid City Hospital, and University of Zurich, Tièchestrasse 99, 8037 Zürich, Switzerland.

出版信息

Pilot Feasibility Stud. 2020 Jul 15;6:101. doi: 10.1186/s40814-020-00645-7. eCollection 2020.

DOI:10.1186/s40814-020-00645-7

PMID:32695433

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7364522/

Abstract

BACKGROUND

Falls represent a major health problem for older adults with cognitive impairment, and the effects of exercise for fall reduction are understudied in this population. This pilot randomized controlled trial evaluated the feasibility, safety, and exploratory effectiveness of a Dalcroze eurhythmics program and a home exercise program designed for fall prevention in older adults with mild cognitive impairment (MCI) or early dementia.

METHODS

For this three-arm, single-blind, 12-month randomized controlled pilot trial, we recruited community-dwelling women and men age 65 years and older with MCI or early dementia through participating memory clinics in Zurich, Switzerland. Participants were randomly assigned to a Dalcroze eurhythmics group program, a simple home exercise program (SHEP), or a non-exercise control group. All participants received 800 IU of vitamin D per day. The main objective of the study was to test the feasibility of recruitment and safety of the interventions. Additional outcomes included fall rate, gait performance, and cognitive function.

RESULTS

Over 12 months, 221 older adults were contacted and 159 (72%) were screened via telephone. Following screening, 12% (19/159) met the inclusion criteria and were willing to participate. One participant withdrew at the end of the baseline visit and 18 were randomized to Dalcroze eurhythmics ( = 7), SHEP ( = 5), or control ( = 6). Adherence was similarly low in the Dalcroze eurhythmics group (56%) and in the SHEP group (62%; = 0.82). Regarding safety and pilot clinical endpoints, there were no differences between groups.

CONCLUSION

The MOVE for your MIND pilot study showed that recruitment of older adults with MCI or early dementia for long-term exercise interventions is challenging. While there were no safety concerns, adherence to both exercise programs was low.

TRIAL REGISTRATION

ClinicalTrials.gov, NCT02279316. Registered on 31 October 2014.

摘要

背景

跌倒对认知障碍的老年人来说是一个主要的健康问题，而运动对减少跌倒的影响在这一人群中尚未得到充分研究。这项初步随机对照试验评估了一种达克罗兹韵律操计划和一种为预防轻度认知障碍（MCI）或早期痴呆的老年人跌倒而设计的家庭锻炼计划的可行性、安全性和探索性效果。

方法

在这项三臂、单盲、为期12个月的随机对照试验中，我们通过瑞士苏黎世的参与性记忆诊所招募了年龄在65岁及以上、患有MCI或早期痴呆的社区居住的女性和男性。参与者被随机分配到达克罗兹韵律操组计划、简单家庭锻炼计划（SHEP）或非运动对照组。所有参与者每天服用800国际单位的维生素D。该研究的主要目的是测试招募的可行性和干预措施的安全性。其他结果包括跌倒率、步态表现和认知功能。

结果

在12个月的时间里，联系了221名老年人，通过电话筛选出159名（72%）。筛选后，12%（19/159）符合纳入标准并愿意参与。一名参与者在基线访视结束时退出，18人被随机分配到达克罗兹韵律操组（n = 7）、SHEP组（n = 5）或对照组（n = 6）。达克罗兹韵律操组（56%）和SHEP组（62%；P = 0.82）的依从性同样较低。关于安全性和初步临床终点，各组之间没有差异。