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结直肠癌实验模型的研究进展与应用概述

Overview of research progress and application of experimental models of colorectal cancer.

作者信息

Liu Li, Yan Qiuying, Chen Zihan, Wei Xiaoman, Li Lin, Tang Dongxin, Tan Jiani, Xu Changliang, Yu Chengtao, Lai Yueyang, Fan Minmin, Tao Lihuiping, Shen Weixing, Li Liu, Wu Mianhua, Cheng Haibo, Sun Dongdong

机构信息

School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.

Collaborative Innovation Center of Jiangsu Province of Cancer Prevention and Treatment of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China.

出版信息

Front Pharmacol. 2023 Jul 4;14:1193213. doi: 10.3389/fphar.2023.1193213. eCollection 2023.

DOI:10.3389/fphar.2023.1193213
PMID:37469864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10352992/
Abstract

Colorectal cancer (CRC) is the third most common malignancy in terms of global tumor incidence, and the rates of morbidity and mortality due to CRC are rising. Experimental models of CRC play a vital role in CRC research. Clinical studies aimed at investigating the evolution and mechanism underlying the formation of CRC are based on cellular and animal models with broad applications. The present review classifies the different experimental models used in CRC research, and describes the characteristics and limitations of these models by comparing the research models with the clinical symptoms. The review also discusses the future prospects of developing new experimental models of CRC.

摘要

就全球肿瘤发病率而言，结直肠癌（CRC）是第三大常见恶性肿瘤，并且CRC导致的发病率和死亡率正在上升。CRC的实验模型在CRC研究中起着至关重要的作用。旨在研究CRC形成的演变和机制的临床研究是基于具有广泛应用的细胞和动物模型。本综述对CRC研究中使用的不同实验模型进行了分类，并通过将研究模型与临床症状进行比较来描述这些模型的特点和局限性。该综述还讨论了开发CRC新实验模型的未来前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9c2/10352992/68546dbb8977/fphar-14-1193213-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9c2/10352992/6ca6e7c0f91b/fphar-14-1193213-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9c2/10352992/69718c24dd74/fphar-14-1193213-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9c2/10352992/c452effa1c52/fphar-14-1193213-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9c2/10352992/68546dbb8977/fphar-14-1193213-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9c2/10352992/6ca6e7c0f91b/fphar-14-1193213-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9c2/10352992/7fea12a87aaa/fphar-14-1193213-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9c2/10352992/69718c24dd74/fphar-14-1193213-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9c2/10352992/c452effa1c52/fphar-14-1193213-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9c2/10352992/68546dbb8977/fphar-14-1193213-g005.jpg

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Biol Trace Elem Res. 2023 Aug;201(8):3746-3754. doi: 10.1007/s12011-022-03458-2. Epub 2022 Oct 24.
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Associations of cigarette smoking, alcohol drinking and body mass index with survival after colorectal cancer diagnosis by anatomic subsite: a prospective patient cohort study in Japan.吸烟、饮酒和体重指数与结直肠癌解剖部位生存的相关性：日本前瞻性患者队列研究。
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Impact of colorectal cancer screening on incidence, mortality and surgery rates: Evidences from programs based on the fecal immunochemical test in Italy.
Colorectal Organoids: Models, Imaging, Omics, Therapy, Immunology, and Ethics.
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Cells. 2025 Mar 19;14(6):457. doi: 10.3390/cells14060457.
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Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies.结直肠癌精准医学方法的进展：从分子剖析到靶向治疗。
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