Scientific Center for Family Health and Human Reproduction Problems, Irkutsk, Russia.
Irkutsk State University, Irkutsk, Russia.
Bull Exp Biol Med. 2023 Jun;175(2):260-264. doi: 10.1007/s10517-023-05846-7. Epub 2023 Jul 21.
We studied the relative length of telomeres in newborns with unrealized perinatal transmission of HIV (zero viral load according to PCR results). A cross-sectional survey of 62 newborns of HIV-infected mothers (Apgar score 8); the control group consisted of 80 healthy newborns (Apgar score 8). DNA extracted from whole venous blood samples was analyzed. In newborns of HIV-infected mothers, the relative length of telomeres was significantly lower (0.69 (0.66; 0.72)) than in newborns of the control group (1.1 (0.97; 1.22)) (p<0.001). No significant differences in the relative length of telomeres were found between newborns of mothers with a viral load at the time of delivery and with undetectable viral load: 0.69 (0.66; 0.73) and 0.69 (0.63; 0.72). These findings indicate that HIV-infection in mothers or exposure to antiretroviral therapy has an impact on the relative telomere length in leukocytes of newborns.
我们研究了未发生围产期 HIV 传播（根据 PCR 结果病毒载量为零）的新生儿端粒的相对长度。对 62 名 HIV 感染母亲的新生儿（阿普加评分 8）进行了横断面调查；对照组由 80 名健康新生儿（阿普加评分 8）组成。从全静脉血样中提取 DNA 进行分析。与对照组（1.1（0.97；1.22））相比，HIV 感染母亲的新生儿端粒的相对长度明显较低（0.69（0.66；0.72））（p<0.001）。在分娩时病毒载量可检测到和不可检测到的母亲所生新生儿之间，端粒的相对长度无显著差异：0.69（0.63；0.72）和 0.69（0.66；0.73）。这些发现表明，母亲的 HIV 感染或接触抗逆转录病毒疗法会影响新生儿白细胞的相对端粒长度。
