Centre for Sport Nutrition and Health, Centre for Nutritional Ecology, School of Physical Education (Main Campus), Zhengzhou University, Zhengzhou, China.
Charles Perkins Centre and School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, Australia.
Int J Food Sci Nutr. 2023 Sep;74(5):589-605. doi: 10.1080/09637486.2023.2235899. Epub 2023 Jul 20.
Growing evidence supports the efficacy of ketogenic diets for inducing weight loss, but there are also potential health risks due to their unbalanced nutrient composition. We aim at assessing relative effectiveness of a balanced diet and ketogenic diet for reversing metabolic syndrome in a diet-induced C57BL/6J mouse model. Mice were fed high-fat diet to induce obesity. Obese individuals were then fed either ketogenic or balanced diets as an obesity intervention. Serum, liver, fat and faecal samples were analysed. We observed that both diet interventions led to significant decrease in body weight. The ketogenic intervention was less effective in reducing adipocyte cell size and led to dyslipidaemia. The composition of the gut microbiome in the balanced diet intervention was more similar to the non-obese control group and had improved functional attributes. Our results indicate intervention with balanced diets ameliorates obesity more safely and effectively than ketogenic diets in diet-induced obesity mouse model.
越来越多的证据支持生酮饮食在诱导体重减轻方面的功效，但由于其营养成分不均衡，也存在潜在的健康风险。我们旨在评估均衡饮食和生酮饮食在逆转饮食诱导的 C57BL/6J 小鼠模型代谢综合征方面的相对有效性。 给小鼠喂食高脂肪饮食以诱导肥胖。然后，肥胖个体分别用生酮或均衡饮食进行肥胖干预。分析血清、肝脏、脂肪和粪便样本。我们观察到两种饮食干预都显著降低了体重。生酮干预在减小脂肪细胞大小方面效果较差，并导致血脂异常。均衡饮食干预的肠道微生物组组成更接近非肥胖对照组，并具有改善的功能属性。我们的结果表明，与生酮饮食相比，在饮食诱导的肥胖小鼠模型中，用均衡饮食进行干预更安全、更有效地改善肥胖。
