Dunlop E M, Al-Egaily S S, Houang E T
JAMA. 1979 Jun 8;241(23):2538-40.
Treponemicidal levels of penicillin in the CSF were not obtained following intramuscular (IM) injections of 600,000 IU of penicillin G procaine along with 2% aluminum monostearate (PAM). Treponemicidal levels of penicillin in the CSF were achieved in 31 patients by probenecid, 500 mg/6 hr by mouth, with penicillin G, 500,000 IU by IM injection, and by probenecid every six hours by mouth and IM injections of penicillin G procaine once a day in two of three patients following injections of 600,000 IU, in four of five following 1.2 million IU, and in three (now all nine) following 2.4 million IU.
肌肉注射60万单位普鲁卡因青霉素G（同时加入2%单硬脂酸铝）后，脑脊液中未达到杀梅毒螺旋体水平的青霉素浓度。31例患者通过口服丙磺舒（500mg/每6小时）联合肌肉注射50万单位青霉素G，以及3例患者中有2例在注射60万单位后、5例患者中有4例在注射120万单位后、5例患者中有3例（现9例患者全部如此）在注射240万单位后，采用口服丙磺舒每6小时一次联合每天一次肌肉注射普鲁卡因青霉素G的方式，脑脊液中达到了杀梅毒螺旋体水平的青霉素浓度。
