梅毒长效治疗方案期间脑脊液（CSF）中的青霉素浓度。
Penicillin concentrations in cerebrospinal fluid (CSF) during repository treatment regimen for syphilis.
作者信息
van der Valk P G, Kraai E J, van Voorst Vader P C, Haaxma-Reiche H, Snijder J A
机构信息
Department of Dermatovenereology, University Hospital, Groningen, The Netherlands.
出版信息
Genitourin Med. 1988 Aug;64(4):223-5. doi: 10.1136/sti.64.4.223.
Abstract
Penicillin concentrations in cerebrospinal fluid (CSF) were measured in 40 asymptomatic patients with syphilis, 10 of whom had neurosyphilis. The patients were treated with 2.4 MIU procaine penicillin a day intramuscularly in combination with 500 mg probenecid every six hours orally. This intramuscular treatment regimen did not consistently yield treponemicidal penicillin concentrations in the CSF (subtreponemicidal CSF concentrations were found in 17 patients, four of whom had neurosyphilis). These data provide additional evidence that the cure of asymptomatic neurosyphilis is not guaranteed by intramuscular penicillin treatment.
摘要
对40例无症状梅毒患者的脑脊液（CSF）青霉素浓度进行了测定，其中10例患有神经梅毒。患者接受每日240万单位普鲁卡因青霉素肌肉注射，同时每6小时口服500毫克丙磺舒。这种肌肉注射治疗方案未能在脑脊液中持续产生杀梅毒螺旋体的青霉素浓度（17例患者脑脊液中发现低于杀梅毒螺旋体浓度，其中4例患有神经梅毒）。这些数据提供了额外证据，表明肌肉注射青霉素治疗不能保证治愈无症状神经梅毒。
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