Weickenmeier Johannes
Department of Mechanical Engineering, Stevens Institute of Technology, Hoboken, NJ 07030, United States of America.
Brain Multiphys. 2023;4. doi: 10.1016/j.brain.2023.100068. Epub 2023 Apr 24.
The human brain remains an endless source of wonder and represents an intruiging scientific frontier. Multiphysics approaches naturally lend themselves to combine our extensive knowledge about the neurobiology of aging and diseases with mechanics to better capture the multiscale behavior of the brain. Our group uses experimental methods, medical image analysis, and constitutive modeling to develop better disease models with the long-term goal to improve diagnosis, treatment, and ultimately enable prevention of many prevalent age- and disease-related brain changes. In the present perspective, we outline on-going work related to neurodevelopment, aging, and neurodegenerative disease.
人类大脑一直是无尽的惊奇之源，代表着一个引人入胜的科学前沿。多物理场方法自然地有助于将我们关于衰老和疾病神经生物学的广泛知识与力学相结合，以更好地捕捉大脑的多尺度行为。我们的团队使用实验方法、医学图像分析和本构模型来开发更好的疾病模型，长期目标是改善诊断、治疗，并最终预防许多与年龄和疾病相关的常见脑部变化。在本观点中，我们概述了与神经发育、衰老和神经退行性疾病相关的正在进行的工作。
