Yano T, Nakagawa A, Tsuji M, Noda K
Life Sci. 1986 Sep 22;39(12):1043-50. doi: 10.1016/0024-3205(86)90195-5.
The skin permeabilities of a series of eight salicylates and ten non-steroidal anti-inflammatory drugs were investigated in human subjects. The logarithms of % absorption through intact skin and of n-octanol/water partition coefficients (log P) of the test compounds were plotted against one another, and a parabolic relationship was obtained in both compound series.
在人体受试者中研究了一系列8种水杨酸盐和10种非甾体抗炎药的皮肤渗透性。将受试化合物通过完整皮肤的吸收百分比的对数与正辛醇/水分配系数（log P）相互作图，在两个化合物系列中均得到抛物线关系。
