Fernandes Quero Reverson, Jesus Dosil Pereira de, Fracassi da Silva José Alberto
Institute of Chemistry, State University of Campinas, Campinas, SP, 13083-861, Brazil.
Instituto Nacional de Ciência e Tecnologia em Bioanalítica (INCTBio), Campinas, SP, Brazil.
Lab Chip. 2023 Aug 8;23(16):3694-3703. doi: 10.1039/d3lc00356f.
Advances in the instrumentation and materials for photopolymerization 3D printing aided the use of this powerful technique in the fabrication of microfluidic devices. The costs of printers and supplies have been reduced to the point where this technique becomes attractive for prototyping microfluidic systems with good resolution. With all the development of multi-material 3D printers, most of the microfluidic devices prepared by photopolymerization 3D printing are based on a single substrate material. We developed a digital light processing multi-material 3D printer where two or more resins can be used to prepare complex objects and functional microfluidic devices. The printer is based on a vat inclination system and embedded peristaltic pumps that allow the injection and removal of resins and cleaning step between material changes. Although we have built the whole system, the modification can be incorporated into commercially available printers. Using a high-resolution projector, microfluidic channels as narrow as 43 μm were obtained. We demonstrate the printing of multi-material objects containing flexible, rigid, water-soluble, fluorescent, phosphorescent, and conductive (containing PEDOT or copper nanoparticles) resins. An example of a microfluidic chip containing electrodes for electrochemical detection is also presented.
用于光聚合3D打印的仪器和材料的进步有助于在微流控设备制造中使用这种强大的技术。打印机和耗材的成本已降低到这种技术对于制造具有良好分辨率的微流控系统具有吸引力的程度。随着多材料3D打印机的不断发展，大多数通过光聚合3D打印制备的微流控设备都基于单一基底材料。我们开发了一种数字光处理多材料3D打印机，其中可以使用两种或更多种树脂来制备复杂物体和功能性微流控设备。该打印机基于槽倾斜系统和嵌入式蠕动泵，允许在材料更换之间注入和去除树脂以及进行清洗步骤。虽然我们构建了整个系统，但这种改进可以整合到市售打印机中。使用高分辨率投影仪，获得了窄至43μm的微流控通道。我们展示了包含柔性、刚性、水溶性、荧光、磷光和导电（包含PEDOT或铜纳米颗粒）树脂的多材料物体的打印。还展示了一个包含用于电化学检测的电极的微流控芯片示例。
