Department of Geriatrics, Zhejiang Provincial Key Laboratory of Geriatrics, Zhejiang Hospital, No. 1229, Gudun Road, 310013, Hangzhou, China.
School of Pharmacy, Hangzhou Medical College, Hangzhou, China.
J Transl Med. 2023 Jul 21;21(1):492. doi: 10.1186/s12967-023-04321-1.
Diet may influence biological aging and the discrepancy (∆age) between a subject's biological age (BA) and chronological age (CA). We aimed to investigate the correlation of dietary flavonoids with the ∆age of organs (heart, kidney, liver) and the whole body.
A total of 3193 United States adults were extracted from the National Health and Nutrition Examination Survey (NHANES) in 2007-2008 and 2017-2018. Dietary flavonoids intake was assessed using 24-h dietary recall method. Multiple linear regression analysis was performed to evaluate the association of dietary flavonoids intake with the ∆age of organs (heart, kidney, liver) and the whole body. BA was computed based on circulating biomarkers, and the resulting ∆age was tested as an outcome in linear regression analysis.
The ∆age of the whole body, heart, and liver was inversely associated with higher flavonoids intake (the whole body ∆age β = - 0.58, cardiovascular ∆age β = - 0.96, liver ∆age β = - 3.19) after adjustment for variables. However, higher flavonoids intake positively related to renal ∆age (β = 0.40) in participants with chronic kidney disease (CKD). Associations were influenced by population characteristics, such as age, health behavior, or chronic diseases. Anthocyanidins, isoflavones and flavones had the strongest inverse associations between the whole body ∆age and cardiovascular ∆age among all the flavonoids subclasses.
Flavonoids intake positively contributes to delaying the biological aging process, especially in the heart, and liver organ, which may be beneficial for reducing the long-term risk of cardiovascular or liver disease.
饮食可能会影响生物年龄以及个体的生物年龄（BA）与实际年龄（CA）之间的差异（∆age）。我们旨在研究饮食类黄酮与器官（心脏、肾脏、肝脏）和全身 ∆age 的相关性。
从 2007-2008 年和 2017-2018 年的国家健康和营养检查调查（NHANES）中提取了 3193 名美国成年人的数据。采用 24 小时膳食回顾法评估饮食类黄酮的摄入量。采用多元线性回归分析评估饮食类黄酮摄入量与器官（心脏、肾脏、肝脏）和全身 ∆age 的相关性。BA 根据循环生物标志物计算，所得 ∆age 作为线性回归分析中的结果进行检验。
在调整了变量后，全身、心脏和肝脏的 ∆age 与较高的类黄酮摄入量呈负相关（全身 ∆ageβ = -0.58，心血管 ∆ageβ = -0.96，肝脏 ∆ageβ = -3.19）。然而，在患有慢性肾脏病（CKD）的患者中，较高的类黄酮摄入量与肾脏 ∆age 呈正相关（β = 0.40）。这些关联受人群特征（如年龄、健康行为或慢性疾病）的影响。在所有类黄酮亚类中，花色苷、异黄酮和黄酮类化合物与全身 ∆age 和心血管 ∆age 之间具有最强的负相关关系。
类黄酮的摄入量与延缓生物衰老过程呈正相关，尤其是在心脏和肝脏器官，这可能有助于降低心血管疾病或肝脏疾病的长期风险。
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