Jiang Chenyu, Luo Jingyao, Shao Yaojian
Department of Geriatric, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang, 318000, China.
Department of Oncology Rehabilitation, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, 318000, China.
BMC Gastroenterol. 2024 Dec 18;24(1):455. doi: 10.1186/s12876-024-03551-x.
Dietary adjustment has consistently been regarded as an effective and health way for both the prevention and treatment of constipation. Several researches suggest a significant correlation between dietary flavonoids intake and gut microbiota, while the relationship between dietary flavonoids and constipation has not been reported. The objective of this study is to investigate the relationship between flavonoids intake and constipation.
This cross-sectional analysis was based on data from the National Health and Nutrition Examination Survey (NHANES) collected from 2007 to 2010. The dietary flavonoid and subclasses intake value were obtained from the United States Department of Food and Nutrient Database for Dietary Studies (FNDDS), while constipation was defined using the stool consistency or frequency. Relationships between total and six main flavonoid subclasses intake constipation were investigated using weighted logistic regression approach.
The study revealed a negative association between isoflavones, anthocyanidins, flavanones, flavones, flavonols, and total flavonoid intake and constipation, with significant p-trends of < 0.05. Following multivariate adjustment, decreased odds of constipation could still be observed in the highest quartiles of anthocyanidins compared with those in the reference quartiles (p-value = 0.03). Ln-transformed anthocyanidins exhibited a statistically significant nonlinear association with constipation, displaying an inverted U-shaped pattern. When anthocyanidins intake exceeded 0.92 mg, the rate of constipation trended downward with increases in anthocyanidins intake.
Our study demonstrated that higher dietary flavonoids intake can reduce the incidence of constipation in the adult US population. In addition, the negative association between anthocyanin intake and constipation was more stable compared to other subclasses.
饮食调整一直被视为预防和治疗便秘的有效且健康的方法。多项研究表明饮食中黄酮类化合物的摄入量与肠道微生物群之间存在显著相关性，而饮食黄酮类化合物与便秘之间的关系尚未见报道。本研究的目的是调查黄酮类化合物摄入量与便秘之间的关系。
本横断面分析基于2007年至2010年收集的美国国家健康与营养检查调查（NHANES）的数据。饮食黄酮类化合物及其亚类的摄入量数据来自美国食品与营养膳食研究数据库（FNDDS），而便秘则根据粪便稠度或频率来定义。使用加权逻辑回归方法研究总黄酮类化合物及其六个主要亚类的摄入量与便秘之间的关系。
研究发现异黄酮、花青素、黄烷酮、黄酮、黄酮醇和总黄酮摄入量与便秘之间呈负相关，p趋势均<0.05，具有统计学意义。经过多变量调整后，与参考四分位数相比，花青素摄入量最高的四分位数人群便秘的几率仍然较低（p值 = 0.03）。对数转换后的花青素与便秘呈现出具有统计学意义的非线性关联，呈倒U形模式。当花青素摄入量超过0.92毫克时，便秘发生率随花青素摄入量的增加而呈下降趋势。
我们的研究表明，在美国成年人群中，较高的饮食黄酮类化合物摄入量可降低便秘的发生率。此外，与其他亚类相比，花青素摄入量与便秘之间的负相关更为稳定。
