Department of Neurology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China.
Department of Neurology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China.
J Psychosom Res. 2023 Oct;173:111468. doi: 10.1016/j.jpsychores.2023.111468. Epub 2023 Aug 18.
Flavonoids may have a protective effect against depression. The purpose of this study was to examine whether flavonoid intake was associated with depression.
This is an observational cross-sectional study. We evaluated a sample of 8183 adults from the National Health and Nutrition Examination Survey (NHANES), 2007-2010. The participants had an average age of 46.7 years, and 48.4% of them were male. Flavonoid intake was obtained through dietary recall interviews, and it included six subclasses: isoflavones, anthocyanidins, flavan-3-ols, flavanones, flavones, and flavonols. Depression was identified using the Patient Health Questionnaire (PHQ-9). Logistic regression was utilized to evaluate the association between flavonoid intake and depression. Restricted cubic splines (RCS) were utilized to investigate nonlinear associations. Differences between subgroups were explored. Mediation analysis was used to explore confounding/mediating factors. These models were adjusted for age, sex, race/ethnicity, poverty status, education, smoking status, alcohol consumption, BMI, energy intake, physical activity, and chronic diseases.
There were 765 individuals with depression (PHQ-9 score ≥ 10) in the sample. After adjusting for covariates, flavanones, flavones, and total flavonoid intake were associated with a lower likelihood of depression (OR (95% CI): 0.73(0.64,0.84); 0.36(0.21,0.63); 0.86(0.74,0.99), respectively). A significant inverse correlation was observed between flavonoid consumption and the somatic symptom score of the PHQ-9. We observed a stronger association between flavonoids and depression in non-Hispanic white groups. The relationship between the total flavonoid intake and depression was explained to some extent by sleep duration (13.8%).
Flavonoid intake was associated with lower odds of depression.
类黄酮可能对抑郁症有保护作用。本研究旨在探讨类黄酮的摄入量是否与抑郁症有关。
这是一项观察性的横断面研究。我们评估了 2007-2010 年全国健康和营养调查（NHANES）中的 8183 名成年人样本。参与者的平均年龄为 46.7 岁，其中 48.4%为男性。类黄酮的摄入量通过饮食回忆访谈获得，包括六个亚类：异黄酮、花青素、黄烷-3-醇、黄酮醇、黄酮和黄酮醇。使用患者健康问卷（PHQ-9）来确定抑郁。使用逻辑回归来评估类黄酮摄入量与抑郁之间的关系。受限立方样条（RCS）用于研究非线性关系。探讨了亚组之间的差异。使用中介分析来探讨混杂/中介因素。这些模型调整了年龄、性别、种族/民族、贫困状况、教育程度、吸烟状况、饮酒状况、体重指数、能量摄入、身体活动和慢性疾病。
在样本中，有 765 人（PHQ-9 得分≥10）患有抑郁症。在调整了协变量后，黄烷酮、黄酮和总类黄酮的摄入量与较低的抑郁可能性相关（OR（95%CI）：0.73（0.64，0.84）；0.36（0.21，0.63）；0.86（0.74，0.99））。类黄酮的消耗与 PHQ-9 的躯体症状评分呈显著负相关。我们观察到类黄酮与非西班牙裔白人群体的抑郁之间存在更强的关联。总类黄酮摄入量与抑郁之间的关系在一定程度上可以通过睡眠时间（13.8%）来解释。
类黄酮的摄入量与较低的抑郁几率有关。
