Department of Otorhinolaryngology-Head and Neck Surgery, Ningbo No.6 Hospital Affiliated Medical School of Ningbo University, Ningbo, 315040, Zhejiang, China.
Department of Otorhinolaryngology-Head and Neck Surgery, Lihuili Hospital of Ningbo University, Ningbo, 315040, Zhejiang, China.
Cell Commun Signal. 2023 Jul 21;21(1):178. doi: 10.1186/s12964-023-01199-w.
Malignant tumours area leading cause of death globally, accounting for approximately 13% of all deaths. A detailed understanding of the mechanism(s) of the occurrence and development of malignant tumours and identification of relevant therapeutic targets are therefore key to tumour treatment. tsRNAs(tRNA-derived small RNAs)-also known as TRFs (tRNA-derived fragments), tiRNAs (tRNA-derived stress-induced RNAs), tRNA halves, etc.-are a recently identified class of small noncoding RNAs that are generated from mature tRNA or tRNA precursors through cleavage by enzymes such as angiogenin, Dicer, RNase Z, and RNase P. Several studies have confirmed that dysregulation of tsRNAs is closely related to the tumorigenesis of breast cancer, nasopharyngeal cancer, lung cancer, and so on. Furthermore, research indicates that tsRNAs can be used as clinical diagnostic markers and therapeutic targets for cancer. In our review, we summarized the recent research progress on the role and clinical application of tsRNAs in tumorigenesis and progression. Video Abstract.
恶性肿瘤是全球主要的死亡原因，约占所有死亡人数的 13%。因此，详细了解恶性肿瘤发生和发展的机制以及鉴定相关的治疗靶点是肿瘤治疗的关键。tsRNAs（tRNA 衍生的小 RNA）——也称为 TRFs（tRNA 衍生的片段）、tiRNAs（tRNA 衍生的应激诱导 RNA）、tRNA 半分子等——是最近发现的一类小非编码 RNA，通过酶（如血管生成素、Dicer、RNase Z 和 RNase P）从成熟 tRNA 或 tRNA 前体中切割产生。几项研究证实，tsRNAs 的失调与乳腺癌、鼻咽癌、肺癌等的肿瘤发生密切相关。此外，研究表明 tsRNAs 可以作为癌症的临床诊断标志物和治疗靶点。在我们的综述中，我们总结了 tsRNAs 在肿瘤发生和进展中的作用及其临床应用的最新研究进展。视频摘要。
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