Chirurgia (Bucur). 2023 Jun;118(3):260-271. doi: 10.21614/chirurgia.2023.v.118.i.3.p.260.
Prior research linked a high preoperative neutrophil-to-lymphocyte ratio (NLR) to a worse prognosis in individuals with a variety of malignancies. This study aimed to establish the prognostic and predictive usefulness of preoperative NLR in colorectal cancer (CRC) patients and to identify an appropriate cut-off value for the NLR. We enrolled a total of 195 patients that underwent surgery for stage II and III colorectal cancer that required adjuvant chemotherapy as well as stage IV colorectal cancer patients treated with palliative intent. The mean NLR value was 3.42 +- 2.27. We used a receiver operating characteristic curve to estimate the optimum NLR cut-off value at 3. Patients with a NLR value above 3 were classified as high-NLR, while patients with a NLR below 3 were classified as low-NLR; Results Overall survival (OS) and progression-free survival (PFS) were significantly reduced in high-NLR patients. The overall response rate (ORR) was also lower in high-NLR patients. Conclusions Preoperative NLR is an accessible measurement that seems to have prognostic and predictive value in patients with colorectal cancer.
先前的研究表明，高术前中性粒细胞与淋巴细胞比值（NLR）与各种恶性肿瘤患者的预后较差有关。本研究旨在确定术前 NLR 在结直肠癌（CRC）患者中的预后和预测价值，并确定 NLR 的适当临界值。我们共纳入了 195 名接受手术治疗的 II 期和 III 期结直肠癌患者，这些患者需要辅助化疗，以及接受姑息治疗的 IV 期结直肠癌患者。平均 NLR 值为 3.42+-2.27。我们使用受试者工作特征曲线来估计最佳 NLR 临界值为 3。NLR 值高于 3 的患者被归类为高 NLR，而 NLR 值低于 3 的患者被归类为低 NLR；结果高 NLR 患者的总生存期（OS）和无进展生存期（PFS）明显降低。高 NLR 患者的总体缓解率（ORR）也较低。结论术前 NLR 是一种易于测量的指标，似乎对结直肠癌患者具有预后和预测价值。
