Iqbal Kisa, Alhomrany Rami, Berman Louis H, Chogle Sami
Department of Endodontics, Boston University Henry M. Goldman School of Dental Medicine, Boston, Massachusetts.
Department of Restorative Dental Sciences, College of Dentistry, Najran University, Najran, Kingdom of Saudi Arabia.
J Endod. 2023 Oct;49(10):1238-1248. doi: 10.1016/j.joen.2023.07.011. Epub 2023 Jul 21.
The elimination of biofilms during root canal therapy continues to pose a challenge due to complex anatomies and uninstrumented portions of the root canal system. The incorporation of nanoparticles in endodontic sealers is an area of interest for potentially enhancing antimicrobial activity and improving treatment outcomes. This systematic review evaluated the antimicrobial effects of various nanoparticles in endodontic sealers.
Comprehensive literature review was conducted using the electronic Embase, Web of Science, and PubMed databases followed by citation searching for articles eligible per the inclusion criteria.
A total of 1845 citations were screened, of which 13 articles met the inclusion criteria and were included in this review. All included articles were in vitro studies with low-to-moderate quality assessment scores. The incorporation of select nanoparticles was associated with significant enhancement of antibacterial effects in planktonic and/or biofilm forms, whereas other nanoparticles were not.
The incorporation of certain types and concentrations of nanoparticles into endodontic sealers displayed antimicrobial effects in vitro. The need for well-designed clinical studies translating in vitro findings into clinical practice is warranted. The incorporation of nanoparticles may enhance the antimicrobial properties of endodontic sealers and may improve treatment outcomes.
由于根管系统解剖结构复杂且存在未被器械处理到的部分，在根管治疗过程中消除生物膜仍然是一项挑战。将纳米颗粒纳入牙髓封闭剂是一个备受关注的领域，有望增强抗菌活性并改善治疗效果。本系统评价评估了各种纳米颗粒在牙髓封闭剂中的抗菌作用。
使用电子数据库Embase、Web of Science和PubMed进行全面的文献综述，随后通过引用搜索符合纳入标准的文章。
共筛选了1845条引文，其中13篇文章符合纳入标准并被纳入本综述。所有纳入的文章均为体外研究，质量评估分数为低到中等。某些纳米颗粒的加入与浮游菌和/或生物膜形式的抗菌效果显著增强相关，而其他纳米颗粒则不然。
将某些类型和浓度的纳米颗粒纳入牙髓封闭剂在体外显示出抗菌作用。有必要开展精心设计的临床研究，将体外研究结果转化为临床实践。纳米颗粒的加入可能会增强牙髓封闭剂的抗菌性能，并可能改善治疗效果。
