Ahmed Karam, Nik Abdul Ghani Nik Rozainah, Mahmoud Okba
Conservatives Unit, School of Dental Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, 16150, Malaysia.
Conservative Department, Faculty of Dentistry, Tishk International University, Erbil, Iraq.
Clin Cosmet Investig Dent. 2025 Aug 31;17:423-434. doi: 10.2147/CCIDE.S534254. eCollection 2025.
The aim of this study was to determine the impact of different nanoparticle concentrations with endodontic bioceramic sealer. It was assessed the combination by analyzing the correlation between the degree of conversion (DC) and antibacterial efficacy. And assess the penetration depth into the lateral canals.
The AH Plus bioceramic sealers were mixed with silver nanoparticles (Ag) at different concentrations (2.5%, 5%, 10%). The antibacterial efficacy against Enterococcus faecalis was evaluated utilizing the direct contact test (DCT) at multiple time intervals (immediately, 30 minutes, 1 day, 2 days, and 7 days). The conversion degree was evaluated by FTIR. The penetration depth was evaluated using X-ray examination.
The antibacterial activity increased with higher concentrations of nanoparticles, with silver nanoparticles demonstrating a pronounced effect on E. faecalis. The conversion degree increased with high quantities of silver nanoparticles. Positive, strong relation between the degree of conversion and antimicrobial activity. The penetration depth decreased as nanoparticle concentration increased. A statistically significant difference was seen between the antibacterial activity values and the degree of conversion at different time intervals (P = 0.05).
The highest nanoparticles concentration (10%) has the greatest effect on the antibacterial activity and degree of conversion, the highest nanoparticles concentration decreased the penetration depth into the lateral canals.
本研究的目的是确定不同纳米颗粒浓度与牙髓生物陶瓷封闭剂的影响。通过分析转化率（DC）与抗菌效果之间的相关性来评估这种组合。并评估其向侧支根管的渗透深度。
将AH Plus生物陶瓷封闭剂与不同浓度（2.5%、5%、10%）的银纳米颗粒（Ag）混合。在多个时间间隔（立即、30分钟、1天、2天和7天）使用直接接触试验（DCT）评估对粪肠球菌的抗菌效果。通过傅里叶变换红外光谱（FTIR）评估转化率。使用X射线检查评估渗透深度。
纳米颗粒浓度越高，抗菌活性越高，银纳米颗粒对粪肠球菌显示出显著效果。银纳米颗粒含量越高，转化率越高。转化率与抗菌活性之间呈正相关且关系较强。随着纳米颗粒浓度增加，渗透深度降低。在不同时间间隔下，抗菌活性值与转化率之间存在统计学显著差异（P = 0.05）。
最高纳米颗粒浓度（10%）对抗菌活性和转化率影响最大，最高纳米颗粒浓度降低了向侧支根管的渗透深度。
