Department of Prosthodontics, Faculty of Dentistry, University of the Western Cape, Belville, Cape Town, South Africa.
Physics Department, Faculty of Science (Girl's Branch), Al-Azhar University, Cairo, Egypt.
JMIR Res Protoc. 2024 Oct 11;13:e51351. doi: 10.2196/51351.
Root canal failure and secondary endodontic infection are frequent clinical scenarios in dentistry. The main microorganisms implicated in root canal therapy failure are persistent Enterococcus faecalis, Candida albicans, and Staphylococcus aureus. To combat the impact of disease resistance, scientists are concentrating on alternative antimicrobial root canal sealers. Nanomaterials are a recent development in endodontic materials that exhibit great antimicrobial properties, making them an ideal material choice for root canal sealers.
This systematic review aims to compare the antimicrobial properties of conventional root canal sealers to those incorporating green synthesized nanoparticles between 2010 and 2024.
A well-constructed protocol was established and registered with PROSPERO (CRD42021286373). Ethics approval was obtained from the Biomedical Research and Ethics Committee from the University of the Western Cape (UWC; BM22/1/4). PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols) reporting guidelines were followed. The included criteria demonstrate the green synthesized nanoparticles studies where the nanoparticles (NPs) are incorporated in root canal sealers. MeSH (Medical Subject Headings) terms were used for the search strategy of the systematic electronic databases for articles published in English between 2010 and 2024. The selected databases included Scopus, PubMed, Web of Science, Science Direct, EBSCOhost, SpringerLink, and Wiley Online. A quality assessment tool for laboratory studies will be used to critically appraise the included studies. If applicable, statistical measures (mean, SD, etc) will be used for data analysis and presentation of the results.
The protocol is registered with PROSPERO. A preliminary search was conducted using a determined search strategy across 8 electronic databases, and the review is now complete.
It is anticipated that the results of this systematic review may reveal the increased interest and application for nanoparticle-enhanced root canal sealers. This will aid in the future development of root canal sealants and mitigate the risk of endodontic failure.
PROSPERO CRD42021286373; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=286373.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/51351.
根管治疗失败和二次根管内感染是口腔医学中常见的临床情况。根管治疗失败的主要微生物包括持续存在的粪肠球菌、白色念珠菌和金黄色葡萄球菌。为了应对耐药性的影响，科学家们正在专注于替代抗菌根管封闭剂。纳米材料是根管材料的最新发展，具有很好的抗菌性能，是根管封闭剂的理想材料选择。
本系统评价旨在比较 2010 年至 2024 年间，传统根管封闭剂与包含绿色合成纳米颗粒的根管封闭剂的抗菌性能。
建立了一个精心构建的方案，并在 PROSPERO（CRD42021286373）中进行了注册。伦理批准来自西开普大学生物医学研究和伦理委员会（UWC；BM22/1/4）。遵循 PRISMA-P（系统评价和荟萃分析议定书的首选报告项目）报告准则。纳入标准表明，研究中使用了绿色合成纳米颗粒，纳米颗粒（NPs）被掺入根管封闭剂中。使用 MeSH（医学主题词）术语搜索了 2010 年至 2024 年期间发表的英文文章的系统电子数据库。选定的数据库包括 Scopus、PubMed、Web of Science、Science Direct、EBSCOhost、SpringerLink 和 Wiley Online。将使用实验室研究质量评估工具对纳入的研究进行严格评估。如果适用，将使用统计措施（均值、标准差等）进行数据分析和结果呈现。
该方案已在 PROSPERO 中注册。初步搜索使用确定的搜索策略在 8 个电子数据库中进行，目前已完成综述。
预计本系统评价的结果可能会揭示人们对纳米颗粒增强型根管封闭剂越来越感兴趣和应用。这将有助于未来根管封闭剂的发展，并降低根管治疗失败的风险。
PROSPERO CRD42021286373；https://www.crd.york.ac.uk/prospero/display_record.php？RecordID=286373。
国际注册报告标识符（IRRID）：DERR1-10.2196/51351。
