Department of Industrial and Materials Science, Chalmers University of Technology, 412 96 Göteborg, Sweden.
Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Göteborg, Sweden.
Acta Biomater. 2023 Sep 15;168:42-77. doi: 10.1016/j.actbio.2023.07.023. Epub 2023 Jul 20.
To tackle antimicrobial resistance, a global threat identified by the United Nations, is a common cause of healthcare-associated infections (HAI) and is responsible for significant costs on healthcare systems, a substantial amount of research has been devoted to developing polysaccharide-based strategies that prevent bacterial attachment and biofilm formation on surfaces. Polysaccharides are essential building blocks for life and an abundant renewable resource that have attracted much attention due to their intrinsic remarkable biological potential antibacterial activities. If converted into efficient antibacterial coatings that could be applied to a broad range of surfaces and applications, polysaccharide-based coatings could have a significant potential global impact. However, the ultimate success of polysaccharide-based antibacterial materials will be determined by their potential for use in manufacturing processes that are scalable, versatile, and affordable. Therefore, in this review we focus on recent advances in polysaccharide-based antibacterial coatings from the perspective of fabrication methods. We first provide an overview of strategies for designing polysaccharide-based antimicrobial formulations and methods to assess the antibacterial properties of coatings. Recent advances on manufacturing polysaccharide-based coatings using some of the most common polysaccharides and fabrication methods are then detailed, followed by a critical comparative overview of associated challenges and opportunities for future developments. STATEMENT OF SIGNIFICANCE: Our review presents a timely perspective by being the first review in the field to focus on advances on polysaccharide-based antibacterial coatings from the perspective of fabrication methods along with an overview of strategies for designing polysaccharide-based antimicrobial formulations, methods to assess the antibacterial properties of coatings as well as a critical comparative overview of associated challenges and opportunities for future developments. Meanwhile this work is specifically targeted at an audience focused on featuring critical information and guidelines for developing polysaccharide-based coatings. Including such a complementary work in the journal could lead to further developments on polysaccharide antibacterial applications.
为了解决被联合国确定为全球威胁的抗菌药物耐药性问题，这是导致医疗保健相关感染（HAI）的一个常见原因，并且给医疗系统带来了巨大的成本负担，因此大量研究致力于开发基于多糖的策略，以防止细菌在表面附着和生物膜形成。多糖是生命的基本组成部分，也是一种丰富的可再生资源，由于其内在的显著生物学潜力和抗菌活性，引起了人们的广泛关注。如果将其转化为可以应用于广泛表面和应用的高效抗菌涂层，基于多糖的涂层将具有重大的全球潜在影响。然而，多糖基抗菌材料的最终成功将取决于其在制造过程中的应用潜力，这些制造过程应具有可扩展性、多功能性和可承受性。因此，在本综述中，我们从制造方法的角度关注基于多糖的抗菌涂层的最新进展。我们首先提供了设计基于多糖的抗菌配方的策略概述以及评估涂层抗菌性能的方法。然后详细介绍了使用一些最常见的多糖和制造方法制造多糖基涂层的最新进展，随后对相关挑战和未来发展的机遇进行了批判性的比较概述。
我们的综述从制造方法的角度关注基于多糖的抗菌涂层的最新进展，同时概述了设计基于多糖的抗菌配方的策略、评估涂层抗菌性能的方法以及对相关挑战和未来发展机遇的批判性比较概述，是该领域的第一篇综述，因此具有及时性。同时，这项工作特别针对专注于提供开发多糖基涂层的关键信息和指导方针的受众。在期刊中包含这样的补充工作可能会进一步推动多糖抗菌应用的发展。
