Yi Yugen, Jiang Yan, Zhou Bin, Zhang Ningyi, Dai Jiangyan, Huang Xin, Zeng Qinqin, Zhou Wei
School of Software, Jiangxi Normal University, Nanchang, 330022, China; Jiangxi Provincial Engineering Research Center of Blockchain Data Security and Governance, Nanchang, 330022, China.
School of Software, Jiangxi Normal University, Nanchang, 330022, China.
Comput Biol Med. 2023 Sep;164:107215. doi: 10.1016/j.compbiomed.2023.107215. Epub 2023 Jul 5.
Glaucoma is a leading cause of worldwide blindness and visual impairment, making early screening and diagnosis is crucial to prevent vision loss. Cup-to-Disk Ratio (CDR) evaluation serves as a widely applied approach for effective glaucoma screening. At present, deep learning methods have exhibited outstanding performance in optic disk (OD) and optic cup (OC) segmentation and maturely deployed in CAD system. However, owning to the complexity of clinical data, these techniques could be constrained. Therefore, an original Coarse-to-Fine Transformer Network (C2FTFNet) is designed to segment OD and OC jointly , which is composed of two stages. In the coarse stage, to eliminate the effects of irrelevant organization on the segmented OC and OD regions, we employ U-Net and Circular Hough Transform (CHT) to segment the Region of Interest (ROI) of OD. Meanwhile, a TransUnet3+ model is designed in the fine segmentation stage to extract the OC and OD regions more accurately from ROI. In this model, to alleviate the limitation of the receptive field caused by traditional convolutional methods, a Transformer module is introduced into the backbone to capture long-distance dependent features for retaining more global information. Then, a Multi-Scale Dense Skip Connection (MSDC) module is proposed to fuse the low-level and high-level features from different layers for reducing the semantic gap among different level features. Comprehensive experiments conducted on DRIONS-DB, Drishti-GS, and REFUGE datasets validate the superior effectiveness of the proposed C2FTFNet compared to existing state-of-the-art approaches.
青光眼是全球失明和视力损害的主要原因,因此早期筛查和诊断对于预防视力丧失至关重要。杯盘比(CDR)评估是一种广泛应用于有效青光眼筛查的方法。目前,深度学习方法在视盘(OD)和视杯(OC)分割方面表现出色,并已在计算机辅助诊断(CAD)系统中成熟应用。然而,由于临床数据的复杂性,这些技术可能会受到限制。因此,设计了一种新颖的粗细结合变压器网络(C2FTFNet)来联合分割OD和OC,该网络由两个阶段组成。在粗阶段,为了消除无关组织对视杯和视盘分割区域的影响,我们采用U-Net和圆形霍夫变换(CHT)对视盘的感兴趣区域(ROI)进行分割。同时,在精细分割阶段设计了一个TransUnet3+模型,以从ROI中更准确地提取视杯和视盘区域。在该模型中,为了缓解传统卷积方法导致的感受野限制,在主干网络中引入了一个变压器模块,以捕捉长距离依赖特征,从而保留更多全局信息。然后,提出了一种多尺度密集跳跃连接(MSDC)模块,用于融合不同层的低级和高级特征,以减少不同级别特征之间的语义差距。在DRIONS-DB、Drishti-GS和REFUGE数据集上进行的综合实验验证了所提出的C2FTFNet与现有最先进方法相比具有卓越的有效性。