Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, Interdisciplinary Research Academy, Zhejiang Shuren University, Hangzhou 310015, PR China.
Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou 310014, PR China.
Sci Total Environ. 2023 Nov 15;899:165697. doi: 10.1016/j.scitotenv.2023.165697. Epub 2023 Jul 22.
The emergence of resistance to existing succinate dehydrogenase inhibitor fungicides (SDHIs) calls for the urgent innovation of novel formulations, but also results in an increase information gap on the ecological risks of novel SDHIs especially to non-target organisms. Herein, the environmental behavior and toxicological effects of a novel SDHI, fluindapyr (FIP), were evaluated using earthworm as model non-target organism. Results showed that FIP had a relatively shorter half-live (about 28 days) in artificial soil compared with traditional SDHIs. Besides, FIP exhibited a rapid uptake and bioaccumulation trend in earthworms. For the toxicological effects, FIP suppressed earthworm growth (≥ 5 mg/kg) and reproduction (≥ 1 mg/kg) whereas no lethal effects were observed up to the highest tested concentration of 25 mg/mg. FIP of high exposure concentrations also induced serious epidermis and intestines damage as well as oxidative stress to earthworms after 28-day exposure. In addition, expression of oxidative damage related genes (CAT, CRT, GST, HSP70, SOD) was further verified after FIP exposure. The earthworm Tier 1 RQ also indicated a potential risk for earthworm reproduction. Data presented here may be useful for the risk assessments of FIP in soil ecosystems and help to set appropriate precautions to ensure protection against novel SDHIs.
现有琥珀酸脱氢酶抑制剂（SDHI）类杀菌剂产生抗药性，这迫切需要创新新型制剂，但也导致了新型 SDHI 类化合物对非靶标生物的生态风险信息缺口增大，特别是对非靶标生物。在此，以蚯蚓为模式非靶标生物，评价了新型 SDHI 类化合物氟吡菌酰胺（FIP）的环境行为和毒理学效应。结果表明，与传统 SDHIs 相比，FIP 在人工土壤中的半衰期（约 28 天）相对较短。此外，FIP 在蚯蚓体内呈现出快速吸收和生物累积的趋势。就毒理学效应而言，FIP 抑制蚯蚓的生长（≥5mg/kg）和繁殖（≥1mg/kg），但在最高测试浓度 25mg/mg 时未观察到致死效应。高暴露浓度的 FIP 在 28 天暴露后也会导致蚯蚓表皮和肠道严重受损以及氧化应激。此外，在 FIP 暴露后，还进一步验证了与氧化损伤相关的基因（CAT、CRT、GST、HSP70、SOD）的表达。蚯蚓 Tier 1 RQ 也表明了 FIP 对蚯蚓繁殖存在潜在风险。这里提供的数据可能有助于对 FIP 在土壤生态系统中的风险评估，并有助于制定适当的防范措施，以确保对新型 SDHI 类化合物的保护。
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